English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Genetic diversity of HLA system in two populations from Quintana Roo, Mexico: Cancún and rural Quintana Roo

Medina-Escobedo, C. E., Barquera, R., Ponnandai-Shanmugavel, K. S., Lara-Riegos, J., Bravo-Acevedo, A., Arrieta-Bolaños, E., et al. (2019). Genetic diversity of HLA system in two populations from Quintana Roo, Mexico: Cancún and rural Quintana Roo. Human Immunology. doi:10.1016/j.humimm.2019.07.279.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0004-59C5-A Version Permalink: http://hdl.handle.net/21.11116/0000-0004-5B76-2
Genre: Journal Article

Files

show Files
hide Files
:
shh2309.pdf (Preprint), 2MB
 
File Permalink:
-
Name:
shh2309.pdf
Description:
In Press, Corrected Proof
Visibility:
Private
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Medina-Escobedo, Carolina Elizabeth, Author
Barquera, Rodrigo1, Author              
Ponnandai-Shanmugavel, Komathi Sree, Author
Lara-Riegos, Julio, Author
Bravo-Acevedo, Alicia, Author
Arrieta-Bolaños, Esteban, Author
Clayton, Stephen1, Author              
Hernández-Zaragoza, Diana Iraíz, Author
Zúñiga, Joaquín, Author
Yunis, Edmond J., Author
Bekker-Méndez, Carolina, Author
Granados, Julio, Author
Affiliations:
1Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2074310              

Content

show
hide
Free keywords: HLA, Immunogenetics, Population genetics, Quintana Roo, Admixture
 Abstract: We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 98 Mexicans from the state of Quintana Roo living in the city of Cancún (N = 48) and rural communities (N = 50), to obtain information regarding allelic and haplotypic frequencies and their linkage disequilibrium. We found that the most frequent haplotypes in Quintana Roo include ten Native American and two European haplotypes. Admixture estimates revealed that the main genetic components in Quintana Roo are Native American (80.85 ± 3.70 by ML; 60.20 of Native American haplotypes) and European (15.19 ± 14.25 by ML; 26.02 of European haplotypes), and a less prominent African genetic component (3.96 ± 10.75 by ML; 6.63 of African haplotypes).

Details

show
hide
Language(s): eng - English
 Dates: 2019-07-22
 Publication Status: Published online
 Pages: 3
 Publishing info: -
 Table of Contents: -
 Rev. Method: Internal
 Identifiers: DOI: 10.1016/j.humimm.2019.07.279
Other: shh2309
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Human Immunology
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York, N.Y. : Elsevier
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 0198-8859
CoNE: https://pure.mpg.de/cone/journals/resource/954925492912