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  Genetic diversity of HLA system in two populations from Quintana Roo, Mexico: Cancún and rural Quintana Roo

Medina-Escobedo, C. E., Barquera, R., Ponnandai-Shanmugavel, K. S., Lara-Riegos, J., Bravo-Acevedo, A., Arrieta-Bolaños, E., et al. (2020). Genetic diversity of HLA system in two populations from Quintana Roo, Mexico: Cancún and rural Quintana Roo. Human Immunology, 81(9), 573-575. doi:10.1016/j.humimm.2019.07.279.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0004-59C5-A Version Permalink: https://hdl.handle.net/21.11116/0000-0009-A0DC-A
Genre: Journal Article

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Medina-Escobedo, Carolina Elizabeth, Author
Barquera, Rodrigo1, Author           
Ponnandai-Shanmugavel, Komathi Sree, Author
Lara-Riegos, Julio, Author
Bravo-Acevedo, Alicia, Author
Arrieta-Bolaños, Esteban, Author
Clayton, Stephen1, Author           
Hernández-Zaragoza, Diana Iraíz, Author
Zúñiga, Joaquín, Author
Yunis, Edmond J., Author
Bekker-Méndez, Carolina, Author
Granados, Julio, Author
Affiliations:
1Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2074310              

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Free keywords: HLA, Immunogenetics, Population genetics, Quintana Roo, Admixture
 Abstract: We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 98 Mexicans from the state of Quintana Roo living in the city of Cancún (N = 48) and rural communities (N = 50), to obtain information regarding allelic and haplotypic frequencies and their linkage disequilibrium. We found that the most frequent haplotypes in Quintana Roo include ten Native American and two European haplotypes. Admixture estimates revealed that the main genetic components in Quintana Roo are Native American (80.85 ± 3.70 by ML; 60.20 of Native American haplotypes) and European (15.19 ± 14.25 by ML; 26.02 of European haplotypes), and a less prominent African genetic component (3.96 ± 10.75 by ML; 6.63 of African haplotypes).

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Language(s): eng - English
 Dates: 2019-07-222020-09
 Publication Status: Issued
 Pages: 3
 Publishing info: -
 Table of Contents: -
 Rev. Type: Internal
 Identifiers: DOI: 10.1016/j.humimm.2019.07.279
Other: shh2309
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Title: Human Immunology
Source Genre: Journal
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Publ. Info: New York, N.Y. : Elsevier
Pages: - Volume / Issue: 81 (9) Sequence Number: - Start / End Page: 573 - 575 Identifier: ISSN: 0198-8859
CoNE: https://pure.mpg.de/cone/journals/resource/954925492912