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  Genetic diversity of HLA system in two populations from Chiapas, Mexico: Tuxtla Gutiérrez and rural Chiapas

Barquera, R., Juárez-Nicolás, F., Martínez-Álvarez, J. C., Ponnendai-Shanmugavel, K. S., Hernández-Zaragoza, D. I., Vázquez-Castillo, T. V., et al. (2019). Genetic diversity of HLA system in two populations from Chiapas, Mexico: Tuxtla Gutiérrez and rural Chiapas. Human Immunology. doi:10.1016/j.humimm.2019.07.285.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-59F1-8 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-59F2-7
Genre: Journal Article

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 Creators:
Barquera, Rodrigo1, Author              
Juárez-Nicolás, Francisco, Author
Martínez-Álvarez, Julio César, Author
Ponnendai-Shanmugavel, Komathi Sree1, Author              
Hernández-Zaragoza, Diana Iraíz, Author
Vázquez-Castillo, Tannya Verónica, Author
Arrieta-Bolaños, Esteban, Author
Clayton, Stephen1, Author              
Solís-Martínez, Raúl, Author
Ortega-Yáñez, Andrea, Author
Arrazola-García, María Araceli, Author
Immel, Alexander1, Author              
Bravo-Acevedo, Alicia, Author
Vega-Martínez, María del Rosario, Author
Benítez-Arvizu, Gamaliel, Author
García-Álvarez, Raquel, Author
Martínez-Bezies, Virginia, Author
Escutia-González, Ariadna, Author
Juárez-Barreto, Vicencio, Author
Salgado-Galicia, Norma, Author
Novelo-Garza, Bárbara, AuthorZúñiga, Joaquín, AuthorYunis, Edmond J., AuthorBekker-Méndez, Carolina, AuthorGranados, Julio, Author more..
Affiliations:
1Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2074310              

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Free keywords: HLA, Immunogenetics, Population genetics, Chiapas, Admixture
 Abstract: We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 173 Mexicans from the state of Chiapas living in the city of Tuxtla Gutiérrez (N = 52) and rural communities (N = 121), to obtain information regarding allelic and haplotypic frequencies. We found that the most frequent haplotypes in Chiapas include 12 Native American and one European haplotype. Admixture estimates revealed that the main genetic components in Chiapas are Native American (71.61 ± 0.58 by ML; 53.16 of Native American haplotypes) and European (26.39 ± 5.05 by ML; 25.86 of European haplotypes), and a less prominent African genetic component (2.00 ± 5.20 by ML; 9.77 of African haplotypes).

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Language(s): eng - English
 Dates: 2019-07-22
 Publication Status: Published online
 Pages: 3
 Publishing info: -
 Table of Contents: -
 Rev. Method: Internal
 Identifiers: DOI: 10.1016/j.humimm.2019.07.285
Other: shh2311
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Title: Human Immunology
Source Genre: Journal
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Publ. Info: New York, N.Y. : Elsevier
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 0198-8859
CoNE: https://pure.mpg.de/cone/journals/resource/954925492912