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  Genetic diversity of HLA system in two populations from Campeche, Mexico: Campeche city and rural Campeche

Barquera, R., Lara-Riegos, J., Ponnendai-Shanmugavel, K. S., Immel, A., Arrieta-Bolaños, E., Clayton, S., et al. (2019). Genetic diversity of HLA system in two populations from Campeche, Mexico: Campeche city and rural Campeche. Human Immunology. doi:10.1016/j.humimm.2019.07.281.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-59FB-E Version Permalink: http://hdl.handle.net/21.11116/0000-0004-59FC-D
Genre: Journal Article

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 Creators:
Barquera, Rodrigo1, Author              
Lara-Riegos, Julio, Author
Ponnendai-Shanmugavel, Komathi Sree1, Author              
Immel, Alexander1, Author              
Arrieta-Bolaños, Esteban, Author
Clayton, Stephen1, Author              
Solís-Martínez, Raúl, Author
Bravo-Acevedo, Alicia, Author
Vázquez-Castillo, Tannya Verónica, Author
Hernández-Zaragoza, Diana Iraíz, Author
Vega-Martínez, María del Rosario, Author
Salgado-Galicia, Norma, Author
Medina-Escobedo, Carolina Elizabeth, Author
Zúñiga, Joaquín, Author
Yunis, Edmond J., Author
Bekker-Méndez, Carolina, Author
Granados, Julio, Author
Affiliations:
1Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2074310              

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Free keywords: HLA, Immunogenetics, Population genetics, Campeche, Admixture
 Abstract: We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 81 Mexicans from the state of Campeche living in the city of Campeche (N = 34) and rural communities (N = 47), to obtain information regarding allelic and haplotypic frequencies. We find that the most frequent haplotypes in the state of Campeche include ten Native American, three European, one African and one Asian haplotype. Admixture estimates revealed that the main genetic components in the state of Campeche are Native American (65.56 ± 0.96 by ML; 51.24 of Native American haplotypes), European (34.44 ± 10.94 by ML; 30.25 of European haplotypes), and a virtually absent African genetic component (0.00 ± 10.31 by ML; 9.26 of African haplotypes).

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Language(s): eng - English
 Dates: 2019-07-22
 Publication Status: Published online
 Pages: 3
 Publishing info: -
 Table of Contents: -
 Rev. Method: Internal
 Identifiers: DOI: 10.1016/j.humimm.2019.07.281
Other: shh2312
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Title: Human Immunology
Source Genre: Journal
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Publ. Info: New York, N.Y. : Elsevier
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 0198-8859
CoNE: https://pure.mpg.de/cone/journals/resource/954925492912