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  Genetic diversity of HLA system in seven populations from Veracruz, Mexico: Veracruz city, Coatzacoalcos, Córdoba, Orizaba, Poza Rica, Xalapa and rural Veracruz

Barquera, R., López-Gil, C., Acuña-Alonzo, V., Vega-Martínez, M. d. R., Rodríguez-Munguía, T. J., Martínez-Álvarez, J. C., et al. (2019). Genetic diversity of HLA system in seven populations from Veracruz, Mexico: Veracruz city, Coatzacoalcos, Córdoba, Orizaba, Poza Rica, Xalapa and rural Veracruz. Human Immunology. doi:10.1016/j.humimm.2019.07.292.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-5A07-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-5A08-F
Genre: Journal Article

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Barquera, Rodrigo1, Author              
López-Gil, Concepción, Author
Acuña-Alonzo, Víctor, Author
Vega-Martínez, María del Rosario, Author
Rodríguez-Munguía, Tirzo Jesús, Author
Martínez-Álvarez, Julio César, Author
Arrieta-Bolaños, Esteban, Author
Clayton, Stephen1, Author              
la Cruz, Flor del Rocío Ramos-de, Author
Hernández-Zaragoza, Diana Iraíz, Author
Bravo-Acevedo, Alicia, Author
Benítez-Arvizu, Gamaliel, Author
Arrazola-García, María Araceli, Author
Aquino-Rubio, Guadalupe, Author
Juárez-Barreto, Vicencio, Author
Méndez-Mani, Patricia, Author
Vázquez-Castillo, Tannya Verónica, Author
Salgado-Galicia, Norma, Author
Solís-Martínez, Raúl, Author
de Pavón-Vargas, María los Ángeles, Author
Zúñiga, Joaquín, AuthorYunis, Edmond J., AuthorBekker-Méndez, Carolina, AuthorGranados, Julio, Author more..
Affiliations:
1Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2074310              

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Free keywords: HLA, Immunogenetics, Population genetics, Veracruz, Admixture
 Abstract: We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 1113 Mexicans from the state of Veracruz living in the cities of Coatzacoalcos (N = 55), Orizaba (N = 60), Córdoba (N = 56), Poza Rica (N = 45), Veracruz (N = 171), Xalapa (N = 187) and rural communities (N = 539) to obtain information regarding allelic and haplotypic frequencies. We found that the most frequent haplotypes include 12 Native American haplotypes. Admixture estimates revealed that the main genetic components are Native American (64.93 ± 1.27 by ML; 55.10 of Native American haplotypes) and European (26.56 ± 0.89 by ML; 28.38 of European haplotypes), and a relatively high African genetic component (8.52 ± 1.82 by ML; 8.78 of African haplotypes).

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Language(s): eng - English
 Dates: 2019-07-23
 Publication Status: Published online
 Pages: 4
 Publishing info: -
 Table of Contents: -
 Rev. Method: Internal
 Identifiers: DOI: 10.1016/j.humimm.2019.07.292
Other: shh2314
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Title: Human Immunology
Source Genre: Journal
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Publ. Info: New York, N.Y. : Elsevier
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 0198-8859
CoNE: https://pure.mpg.de/cone/journals/resource/954925492912