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  Genetic diversity of HLA system in two populations from Oaxaca, Mexico: Oaxaca city and rural Oaxaca

Hernández-Hernández, O., Hernández-Zaragoza, D. I., Barquera, R., Warinner, C. G., López-Gil, C., Arrieta-Bolaños, E., et al. (2019). Genetic diversity of HLA system in two populations from Oaxaca, Mexico: Oaxaca city and rural Oaxaca. Human Immunology. doi:10.1016/j.humimm.2019.07.278.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-5ACB-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-5ACC-2
Genre: Journal Article

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 Creators:
Hernández-Hernández, Ofelia, Author
Hernández-Zaragoza, Diana Iraíz, Author
Barquera, Rodrigo1, Author              
Warinner, Christina G.2, Author              
López-Gil, Concepción, Author
Arrieta-Bolaños, Esteban, Author
Clayton, Stephen1, Author              
Bravo-Acevedo, Alicia, Author
la Cruz, Flor del Rocío Ramos-de, Author
Méndez-Mani, Patricia, Author
de Pavón-Vargas, María los Ángeles, Author
Zúñiga, Joaquín, Author
Yunis, Edmond J., Author
Bekker-Méndez, Carolina, Author
Granados, Julio, Author
Affiliations:
1Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2074310              
2Kostbare Kulturen, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2591692              

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Free keywords: HLA, Immunogenetics, Population genetics, Oaxaca, Admixture
 Abstract: We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 636 Mexicans from the state of Oaxaca living in the city of Oaxaca (N = 151) and rural communities (N = 485), to obtain information regarding allelic and haplotypic frequencies. We found that the 13 most frequent haplotypes in Oaxaca are all of putative Native American origin. Admixture estimates revealed that the main genetic components in the state of Oaxaca are Native American (73.12 ± 2.77 by ML; 61.52 of Native American haplotypes) and European (17.36 ± 2.07 by ML; 20.69 of European haplotypes), and a relatively high African genetic component (9.52 ± 0.88 by ML; 8.94 of African haplotypes).

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Language(s): eng - English
 Dates: 2019-07-22
 Publication Status: Published online
 Pages: 4
 Publishing info: -
 Table of Contents: -
 Rev. Method: Internal
 Identifiers: DOI: 10.1016/j.humimm.2019.07.278
Other: shh2315
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Title: Human Immunology
Source Genre: Journal
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Publ. Info: New York, N.Y. : Elsevier
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 0198-8859
CoNE: https://pure.mpg.de/cone/journals/resource/954925492912