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  Genetic diversity of HLA system in three populations from Coahuila, Mexico: Torreón, Saltillo and rural Coahuila

Adalid-Sáinz, C., Barquera, R., Crawford, M. H., Lona-Sánchez, A., Clayton, S., Arrieta-Bolaños, E., et al. (2019). Genetic diversity of HLA system in three populations from Coahuila, Mexico: Torreón, Saltillo and rural Coahuila. Human Immunology. doi:10.1016/j.humimm.2019.07.284.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-5AE0-A Version Permalink: http://hdl.handle.net/21.11116/0000-0004-5AE1-9
Genre: Journal Article

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 Creators:
Adalid-Sáinz, Carmen, Author
Barquera, Rodrigo1, Author              
Crawford, Michael H., Author
Lona-Sánchez, Abraham, Author
Clayton, Stephen1, Author              
Arrieta-Bolaños, Esteban, Author
Delgado-Aguirre, Héctor, Author
González-Medina, Liliana, Author
Pacheco-Ubaldo, Hanna, Author
Hernández-Zaragoza, Diana Iraíz, Author
Bravo-Acevedo, Alicia, Author
Escareño-Montiel, Néstor, Author
Morán-Martínez, Javier, Author
González-Martínez, Marisela del Rocío, Author
Jaramillo-Rodríguez, Yolanda, Author
Salgado-Adame, Antonio, Author
la Cruz, Federico Juárez-de, Author
Zúñiga, Joaquín, Author
Yunis, Edmond J., Author
Bekker-Méndez, Carolina, Author
Granados, Julio, Author more..
Affiliations:
1Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2074310              

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Free keywords: HLA, Immunogenetics, Population genetics, Coahuila, Admixture
 Abstract: We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 684 Mexicans from the state of Coahuila living in Saltillo (N = 72), Torreón (N = 396) and rural communities (N = 216), to obtain information regarding allelic and haplotypic frequencies. We find that the ten most frequent haplotypes found in the state of Coahuila include eight Native American and two European haplotypes. Admixture estimates revealed that the main genetic components in the state of Coahuila are European (49.72 ± 4.18 by ML; 37.49 of European haplotypes) and Native American (45.01 ± 2.69 by ML; 42.98 of Native American haplotypes), while African genetic component is less apparent (5.27 ± 1.88 by ML; 9.92 of African haplotypes).

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Language(s): eng - English
 Dates: 2019-07-23
 Publication Status: Published online
 Pages: 4
 Publishing info: -
 Table of Contents: -
 Rev. Method: Internal
 Identifiers: DOI: 10.1016/j.humimm.2019.07.284
Other: shh2316
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Title: Human Immunology
Source Genre: Journal
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Publ. Info: New York, N.Y. : Elsevier
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 0198-8859
CoNE: https://pure.mpg.de/cone/journals/resource/954925492912