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  Genetic diversity of HLA system in two populations from Tabasco, Mexico: Villahermosa and rural Tabasco

Solís-Martínez, R., Barquera, R., Ponnendai-Shanmugavel, K. S., Vega-Martínez, M. d. R., Vázquez-Castillo, T. V., Arrieta-Bolaños, E., et al. (2019). Genetic diversity of HLA system in two populations from Tabasco, Mexico: Villahermosa and rural Tabasco. Human Immunology. doi:10.1016/j.humimm.2019.07.286.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-5AED-D Version Permalink: http://hdl.handle.net/21.11116/0000-0004-5AEE-C
Genre: Journal Article

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Solís-Martínez, Raúl, Author
Barquera, Rodrigo1, Author              
Ponnendai-Shanmugavel, Komathi Sree1, Author              
Vega-Martínez, María del Rosario, Author
Vázquez-Castillo, Tannya Verónica, Author
Arrieta-Bolaños, Esteban, Author
Clayton, Stephen1, Author              
Hernández-Zaragoza, Diana Iraíz, Author
Bravo-Acevedo, Alicia, Author
Immel, Alexander1, Author              
Salgado-Galicia, Norma, Author
Zúñiga, Joaquín, Author
Yunis, Edmond J., Author
Bekker-Méndez, Carolina, Author
Granados, Julio, Author
Affiliations:
1Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2074310              

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Free keywords: HLA, Immunogenetics, Population genetics, Tabasco, Admixture
 Abstract: We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 224 Mexicans from the state of Tabasco living in the city of Villahermosa (N = 82) and rural communities (N = 142), to obtain information regarding allelic and haplotypic frequencies. We found that the most frequent haplotypes in Tabasco include 13 Native American and two European haplotypes. Admixture estimates revealed that the main genetic components in Tabasco are Native American (67.79 ± 1.59 by ML; 56.25 of Native American haplotypes) and European (27.21 ± 3.97 by ML; 29.91 of European haplotypes), and a less prominent African genetic component (5.01 ± 4.42 by ML; 8.93 of African haplotypes).

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Language(s): eng - English
 Dates: 2019-07-23
 Publication Status: Published online
 Pages: 3
 Publishing info: -
 Table of Contents: -
 Rev. Method: Internal
 Identifiers: DOI: 10.1016/j.humimm.2019.07.286
BibTex Citekey: shh2317
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Title: Human Immunology
Source Genre: Journal
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Publ. Info: New York, N.Y. : Elsevier
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 0198-8859
CoNE: https://pure.mpg.de/cone/journals/resource/954925492912