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  Glutathione Metabolism in Renal Cell Carcinoma Progression and Implications for Therapies

Xiao, Y., & Meierhofer, D. (2019). Glutathione Metabolism in Renal Cell Carcinoma Progression and Implications for Therapies. International Journal of Molecular Sciences, 20(15): E3672. doi:10.3390/ijms20153672.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-5B9C-7 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-5B9D-6
Genre: Journal Article

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© 2019, The Authors (This article belongs to the Special Issue Physiological and Pathological Role of ROS: Benefits and Limitations of Antioxidant Treatment)

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 Creators:
Xiao, Yi1, Author
Meierhofer, David2, Author              
Affiliations:
1Freie Universität Berlin, Fachbereich Biologie, Chemie, Pharmazie, Takustraße 3, 14195 Berlin, Germany, ou_persistent22              
2Mass Spectrometry (Head: David Meierhofer), Scientific Service (Head: Christoph Krukenkamp), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479669              

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Free keywords: Renal cell carcinoma (RCC); reactive oxygen species (ROS); glutathione (GSH) metabolism; cancer therapy; clear cell RCC; papillary RCC; chromophobe RCC
 Abstract: A significantly increased level of the reactive oxygen species (ROS) scavenger glutathione (GSH) has been identified as a hallmark of renal cell carcinoma (RCC). The proposed mechanism for increased GSH levels is to counteract damaging ROS to sustain the viability and growth of the malignancy. Here, we review the current knowledge about the three main RCC subtypes, namely clear cell RCC (ccRCC), papillary RCC (pRCC), and chromophobe RCC (chRCC), at the genetic, transcript, protein, and metabolite level and highlight their mutual influence on GSH metabolism. A further discussion addresses the question of how the manipulation of GSH levels can be exploited as a potential treatment strategy for RCC.

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 Dates: 2019-07-262019-07-26
 Publication Status: Published online
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 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.3390/ijms20153672
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Title: International Journal of Molecular Sciences
  Abbreviation : Int. J. Mol. Sci.
Source Genre: Journal
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Publ. Info: Basel, Switzerland : MDPI AG
Pages: - Volume / Issue: 20 (15) Sequence Number: E3672 Start / End Page: - Identifier: ISSN: 1422-0067
CoNE: https://pure.mpg.de/cone/journals/resource/1422-0067