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  Systematic hydrogen bond manipulations to establish polysaccharide structure‐property correlations

Yu, Y., Tyrikos-Ergas, T., Zhu, Y., Fittolani, G., Bordoni, V., Singhal, A., et al. (2019). Systematic hydrogen bond manipulations to establish polysaccharide structure‐property correlations. Angewandte Chemie International Edition in English. doi:10.1002/anie.201906577.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-627D-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-C805-5
Genre: Journal Article

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 Creators:
Yu, Yang1, Author              
Tyrikos-Ergas, Theodore1, Author              
Zhu, Yuntao2, Author              
Fittolani, Giulio1, Author              
Bordoni, Vittorio1, Author              
Singhal, Ankush3, Author              
Fair, Richard J.4, Author              
Grafmüller, Andrea3, Author              
Seeberger, Peter H.5, Author              
Delbianco, Martina1, Author              
Affiliations:
1Martina Delbianco, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_2559692              
2Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863306              
3Andrea Grafmüller, Theorie & Bio-Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863323              
4Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863286              
5Peter H. Seeberger, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_2040285              

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Free keywords: carbohydrates, automated glycan assembly, structure-propertycorrelation, molecular dynamics, tailor-made materials
 Abstract: A dense hydrogen bond network is responsible for the mechanical and structural properties of polysaccharides. Random derivatization alters thematerial bulk properties by disrupting the hydrogen bonds, but obstructs detailed structure-function correlations. We prepare well-defined unnatural oligosaccharidesincludingmethylated, deoxygenated, deoxyfluorinated, as well as carboxymethylated cellulose and chitin analogueswith full control over degree and patternof substitution.Molecular dynamics simulationsand crystallographic analysis showhow distinct H-bond modifications drastically affect thesolubility, aggregation behaviour, and crystallinityof carbohydratematerials. This systematic approachto establishingdetailed structure-propertycorrelations will guide the synthesis of novel, tailor-made carbohydrate materials.

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 Dates: 2019-07-30
 Publication Status: Published online
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Title: Angewandte Chemie International Edition in English
  Abbreviation : Angew. Chem. Int. Ed. Engl.
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 0570-0833