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  Paleo-Eskimo genetic legacy across North America

Flegontov, P., Altinisik, N. E., Changmai, P., Rohland, N., Mallick, S., Bolnick, D. A., et al. (2017). Paleo-Eskimo genetic legacy across North America. bioRxiv, 203018. doi:10.1101/203018.

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 Urheber:
Flegontov, Pavel, Autor
Altinisik, N. Ezgi, Autor
Changmai, Piya, Autor
Rohland, Nadin, Autor
Mallick, Swapan, Autor
Bolnick, Deborah A., Autor
Candilio, Francesca, Autor
Flegontova, Olga, Autor
Jeong, Choongwon1, Autor           
Harper, Thomas K., Autor
Keating, Denise, Autor
Kennett, Douglas J., Autor
Kim, Alexander M., Autor
Lamnidis, Thiseas Christos1, Autor           
Olalde, Iñigo, Autor
Raff, Jennifer, Autor
Sattler, Robert A., Autor
Skoglund, Pontus, Autor
Vajda, Edward J., Autor
Vasilyev, Sergey, Autor
Veselovskaya, Elizaveta, AutorHayes, M. Geoffrey, AutorO’Rourke, Dennis H., AutorPinhasi, Ron, AutorKrause, Johannes1, Autor           Reich, David, AutorSchiffels, Stephan1, Autor            mehr..
Affiliations:
1Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2074310              

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 Zusammenfassung: Paleo-Eskimos were the first people to settle vast regions of the American Arctic around 5,000 years ago, and were subsequently joined and largely displaced around 1,000 years ago by ancestors of the present-day Inuit and Yupik. The genetic relationship between Paleo-Eskimos and Native American populations remains uncertain. We analyze ancient and present-day genome-wide data from the Americas and Siberia, including new data from Alaskan Iñupiat and West Siberian populations, and the first genome-wide DNA from ancient Aleutian Islanders, ancient northern Athabaskans, and a 4,250-year-old individual of the Chukotkan Ust’-Belaya culture. Employing new methods based on rare allele and haplotype sharing as well as established methods based on allele frequency correlations, we show that Paleo-Eskimo ancestry is widespread among populations who speak Na-Dene and Eskimo-Aleut languages. Using phylogenetic modelling with allele frequency correlations and rare variation, we present a comprehensive model for the complex peopling of North America.

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Sprache(n): eng - English
 Datum: 2017-10-13
 Publikationsstatus: Online veröffentlicht
 Seiten: 30
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: - Results
-- Dataset
-- Gradient of Paleo-Eskimo-related ancestry
-- Source of distinct ancestry in Na-Dene
-- No evidence for population turnover in the Aleutian Islands around 1,000 calBP
-- A Paleo-Eskimo with West Siberian ancestry
-- Demographic modelling
- Discussion
- Methods
-- Ancient DNA sampling, extraction and sequencing
-- Sampling present-day populations
-- Dataset preparation
-- ADMIXTURE analysis
-- Principal component analysis (PCA)
-- Admixture modelling with qpWave and qpAdm
-- fineSTRUCTURE clustering
-- Haplotype sharing statistics
-- Dating admixture events using haplotype sharing statistics
-- Rare allele sharing statistics
-- Demographic modelling

 Art der Begutachtung: Keine Begutachtung
 Identifikatoren: DOI: 10.1101/203018
Anderer: shh2323
 Art des Abschluß: -

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Titel: bioRxiv
Genre der Quelle: Webseite
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Seiten: - Band / Heft: - Artikelnummer: 203018 Start- / Endseite: - Identifikator: URI: https://www.biorxiv.org/