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  SAMBADENA hyperpolarization of 13C‐succinate in an MRI: Singlet‐triplet mixing causes polarization loss.

Berner, S., Schmidt, A. B., Zimmermann, M., Pravdivtsev, A. N., Glöggler, S., Hennig, J., et al. (2019). SAMBADENA hyperpolarization of 13C‐succinate in an MRI: Singlet‐triplet mixing causes polarization loss. ChemistryOpen, 8(6), 728-736. doi:10.1002/open.201900139.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-5D3C-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-5D41-B
Genre: Journal Article

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 Creators:
Berner, S., Author
Schmidt, A. B., Author
Zimmermann, M., Author
Pravdivtsev, A. N., Author
Glöggler, S.1, Author              
Hennig, J., Author
von Elverfeldt, D., Author
Hovener, J. B., Author
Affiliations:
1Research Group of NMR Signal Enhancement, MPI for Biophysical Chemistry, Max Planck Society, ou_2396691              

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Free keywords: nuclear magnetic resonance; hyperpolarization; parahydrogen; biomolecules; succinate derivatives
 Abstract: The signal enhancement provided by the hyperpolarization of nuclear spins of biological molecules is a highly promising technique for diagnostic imaging. To date, most C-13-contrast agents had to be polarized in an extra, complex or cost intensive polarizer. Recently, the in situ hyperpolarization of a C-13 contrast agent to >20 % was demonstrated without a polarizer but within the bore of an MRI system. This approach addresses some of the challenges of MRI with hyperpolarized tracers, i. e. elevated cost, long production times, and loss of polarization during transfer to the detection site. Here, we demonstrate the first hyperpolarization of a biomolecule in aqueous solution in the bore of an MRI at field strength of 7 T within seconds. The C-13 nucleus of 1-C-13, 2,3-H-2(2)-succinate was polarized to 11 % corresponding to a signal enhancement of approximately 18.000. Interesting effects during the process of the hydrogenation reaction which lead to a significant loss of polarization have been observed.

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Language(s): eng - English
 Dates: 2019-06-04
 Publication Status: Published online
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1002/open.201900139
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Title: ChemistryOpen
Source Genre: Journal
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Pages: - Volume / Issue: 8 (6) Sequence Number: - Start / End Page: 728 - 736 Identifier: -