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  Ancient origins of low lean mass among South Asians and implications for modern type 2 diabetes susceptibility

Pomeroy, E., Mushrif-Tripathy, V., Cole, T. J., Wells, J. C. K., & Stock, J. T. (2019). Ancient origins of low lean mass among South Asians and implications for modern type 2 diabetes susceptibility. Scientific Reports, 9(1): 10515. doi:10.1038/s41598-019-46960-9.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-6267-A Version Permalink: http://hdl.handle.net/21.11116/0000-0004-6268-9
Genre: Journal Article

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 Creators:
Pomeroy, Emma, Author
Mushrif-Tripathy, Veena, Author
Cole, Tim J., Author
Wells, Jonathan C. K., Author
Stock, Jay T.1, Author              
Affiliations:
1Archaeology, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2074312              

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 Abstract: Living South Asians have low lean tissue mass relative to height, which contributes to their elevated type 2 diabetes susceptibility, particularly when accompanied by obesity. While ongoing lifestyle transitions account for rising obesity, the origins of low lean mass remain unclear. We analysed proxies for lean mass and stature among South Asian skeletons spanning the last 11,000 years (n = 197) to investigate the origins of South Asian low lean mass. Compared with a worldwide sample (n = 2,003), South Asian skeletons indicate low lean mass. Stature-adjusted lean mass increased significantly over time in South Asia, but to a very minor extent (0.04 z-score units per 1,000 years, adjusted R2 = 0.01). In contrast stature decreased sharply when agriculture was adopted. Our results indicate that low lean mass has characterised South Asians since at least the early Holocene and may represent long-term climatic adaptation or neutral variation. This phenotype is therefore unlikely to change extensively in the short term, so other strategies to address increasing non-communicable disease rates must be pursued. © 2019, The Author(s).

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Language(s): eng - English
 Dates: 2019-07-192019-12-01
 Publication Status: Published in print
 Pages: 12
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1038/s41598-019-46960-9
Other: shh2338
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Title: Scientific Reports
  Abbreviation : Sci. Rep.
Source Genre: Journal
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Publ. Info: London, UK : Nature Publishing Group
Pages: - Volume / Issue: 9 (1) Sequence Number: 10515 Start / End Page: - Identifier: ISSN: 2045-2322
CoNE: https://pure.mpg.de/cone/journals/resource/2045-2322