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  Ancient genomes reveal a high diversity of Mycobacterium leprae in medieval Europe

Schuenemann, V. J., Avanzi, C., Krause-Kyora, B., Seitz, A., Herbig, A., Inskip, S., et al. (2018). Ancient genomes reveal a high diversity of Mycobacterium leprae in medieval Europe. PLoS Pathogens, 14(5): e1006997. doi:10.1371/journal.ppat.1006997.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-6329-F Version Permalink: http://hdl.handle.net/21.11116/0000-0004-632A-E
Genre: Journal Article

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 Creators:
Schuenemann, Verena J., Author
Avanzi, Charlotte, Author
Krause-Kyora, Ben1, Author              
Seitz, Alexander, Author
Herbig, Alexander1, Author              
Inskip, Sarah, Author
Bonazzi, Marion, Author
Reiter, Ella, Author
Urban, Christian, Author
Dangvard Pedersen, Dorthe, Author
Taylor, G. Michael, Author
Singh, Pushpendra, Author
Stewart, Graham R., Author
Velemínský, Petr, Author
Likovsky, Jakub, Author
Marcsik, Antónia, Author
Molnár, Erika, Author
Pálfi, György, Author
Mariotti, Valentina, Author
Riga, Alessandro, Author
Belcastro, M. Giovanna, AuthorBoldsen, Jesper L., AuthorNebel, Almut, AuthorMays, Simon, AuthorDonoghue, Helen D., AuthorZakrzewski, Sonia, AuthorBenjak, Andrej, AuthorNieselt, Kay, AuthorCole, Stewart T., AuthorKrause, Johannes1, 2, Author               more..
Affiliations:
1Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2074310              
2MHAAM, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2541699              

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 Abstract: Author summary Many controversies surround leprosy, which is one of the oldest recorded diseases of humankind. The origin and past spread of its main causative agent, Mycobacterium leprae, remain unknown although many attempts have been made to reconstruct its past from historical and archeological sources. Analysis of ancient M. leprae genomes reconstructed from archaeological remains can contribute greatly to reconstructing the origin and evolution of this pathogen. With a new set of ancient M. leprae genomes from Europe, we traced back a so far unrecognized past diversity, which places Europe as a key region for the early spread and worldwide dissemination of leprosy. Our results hint to the potential dynamic changes in the prevalence of different M. leprae strains in Europe during Antiquity, and highlight the need to study ancient pathogen genomes in order to better understand our past.

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Language(s): eng - English
 Dates: 2018-05-10
 Publication Status: Published online
 Pages: 17
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1371/journal.ppat.1006997
Other: shh2345
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Title: PLoS Pathogens
  Other : PLoS Pathog.
Source Genre: Journal
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Publ. Info: San Francisco, CA : Public Library of Science
Pages: - Volume / Issue: 14 (5) Sequence Number: e1006997 Start / End Page: - Identifier: ISSN: 1553-7366
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000018830