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  Palladium-Catalyzed Late-Stage Direct Arene Cyanation

Zhao, D., Xu, P., & Ritter, T. (2019). Palladium-Catalyzed Late-Stage Direct Arene Cyanation. Chem, 5(1), 97-107. doi:10.1016/j.chempr.2018.09.027.

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Genre: Journal Article

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 Creators:
Zhao, Da1, Author              
Xu, Peng1, Author              
Ritter, Tobias1, Author              
Affiliations:
1Research Department Ritter, Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_2040308              

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 Abstract: Methods for direct benzonitrile synthesis are sparse, despite the versatility of cyano groups in organic synthesis and the importance of benzonitriles for the dye, agrochemical, and pharmaceutical industries. We report the first general late-stage aryl C–H cyanation with broad substrate scope and functional-group tolerance. The reaction is enabled by a dual-ligand combination of quinoxaline and an amino acid-derived ligand. The method is applicable to direct cyanation of several marketed small-molecule drugs, common pharmacophores, and organic dyes.

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Language(s): eng - English
 Dates: 2018-08-012018-09-282019-01-10
 Publication Status: Published online
 Pages: 11
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.chempr.2018.09.027
 Degree: -

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Title: Chem
Source Genre: Journal
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Publ. Info: Cambridge, MA : Cell Press
Pages: - Volume / Issue: 5 (1) Sequence Number: - Start / End Page: 97 - 107 Identifier: ISSN: 2451-9294
CoNE: https://pure.mpg.de/cone/journals/resource/24519294