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  Aromatic C–H amination in hexafluoroisopropanol

D'Amato, E. M., Börgel, J., & Ritter, T. (2019). Aromatic C–H amination in hexafluoroisopropanol. Chemical Science, 10(8), 2424-2428. doi:10.1039/C8SC04966A.

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Genre: Journal Article

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 Creators:
D'Amato, Erica M.1, Author
Börgel, Jonas2, Author           
Ritter, Tobias1, 2, Author           
Affiliations:
1Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, USA , ou_persistent22              
2Research Department Ritter, Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_2040308              

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 Abstract: We report a direct radical aromatic amination reaction that provides unprotected anilines with an improvement in the substrate scope compared to prior art. Hydrogen bonding by the solvent hexafluoroisopropanol to anions of cationic species is responsible for increased reactivity and can rationalize the enhancement in substrate scope. Our findings may have bearings on radical additions to arenes for direct C–H functionalization in general.

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Language(s): eng - English
 Dates: 2018-11-072018-12-212019-01-112019-02-28
 Publication Status: Published in print
 Pages: 5
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1039/C8SC04966A
 Degree: -

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Title: Chemical Science
  Other : Chem. Sci.
Source Genre: Journal
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Publ. Info: Cambridge, UK : Royal Society of Chemistry
Pages: - Volume / Issue: 10 (8) Sequence Number: - Start / End Page: 2424 - 2428 Identifier: ISSN: 2041-6520
CoNE: https://pure.mpg.de/cone/journals/resource/2041-6520