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  The conduction pathway of potassium channels is water free under physiological conditions.

Öster, C., Hendriks, K., Kopec, W., Chevelkov, V., Shi, C., Michl, D., et al. (2019). The conduction pathway of potassium channels is water free under physiological conditions. Science Advances, 5(7): eaaw6756. doi:10.1126/sciadv.aaw6756.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-707E-1 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-7082-A
Genre: Journal Article

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Öster, C., Author
Hendriks, K., Author
Kopec, W.1, Author              
Chevelkov, V., Author
Shi, C., Author
Michl, D., Author
Lange, S., Author
Sun, H., Author
de Groot, B. L.1, Author              
Lange, A., Author
Affiliations:
1Research Group of Computational Biomolecular Dynamics, MPI for biophysical chemistry, Max Planck Society, ou_578573              

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 Abstract: Ion conduction through potassium channels is a fundamental process of life. On the basis of crystallographic data, it was originally proposed that potassium ions and water molecules are transported through the selectivity filter in an alternating arrangement, suggesting a "water-mediated" knock-on mechanism. Later on, this view was challenged by results from molecular dynamics simulations that revealed a "direct" knock-on mechanism where ions are in direct contact. Using solid-state nuclear magnetic resonance techniques tailored to characterize the interaction between water molecules and the ion channel, we show here that the selectivity filter of a potassium channel is free of water under physiological conditions. Our results are fully consistent with the direct knock-on mechanism of ion conduction but contradict the previously proposed water-mediated knock-on mechanism.

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Language(s): eng - English
 Dates: 2019-07-31
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1126/sciadv.aaw6756
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Title: Science Advances
Source Genre: Journal
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Pages: 7 Volume / Issue: 5 (7) Sequence Number: eaaw6756 Start / End Page: - Identifier: -