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  Food Perception Primes Hepatic ER Homeostasis via Melanocortin-Dependent Control of mTOR Activation

Brandt, C., Nolte, H., Henschke, S., Engstrom Ruud, L., Awazawa, M., Morgan, D. A., et al. (2018). Food Perception Primes Hepatic ER Homeostasis via Melanocortin-Dependent Control of mTOR Activation. Cell, 175(5), 1321-1335 e20. doi:10.1016/j.cell.2018.10.015.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-0004-71FB-2 Versions-Permalink: https://hdl.handle.net/21.11116/0000-0004-D48B-0
Genre: Zeitschriftenartikel

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https://www.ncbi.nlm.nih.gov/pubmed/30445039 (beliebiger Volltext)
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 Urheber:
Brandt, C.1, Autor
Nolte, H.1, Autor
Henschke, S.1, Autor
Engstrom Ruud, L.1, Autor
Awazawa, M.1, Autor
Morgan, D. A.1, Autor
Gabel, P.1, Autor
Sprenger, H. G.1, Autor
Hess, M. E.1, Autor
Gunther, S.1, Autor
Langer, T.2, Autor
Rahmouni, K.1, Autor
Fenselau, H.1, Autor
Kruger, M.1, Autor
Bruning, J. C.1, Autor
Affiliations:
1Department Jens Brüning, Max Planck Institute for Metabolism Research, Managing Director: Jens Brüning, Max Planck Society, Gleueler Str. 50, 50931 Köln, DE, ou_2149643              
2Max Planck Institute for Biology of Ageing, Max Planck Society, Joseph-Stelzmann-Str. 9b, D-50931 Cologne, DE, ou_1942284              

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 Zusammenfassung: Adaptation of liver to the postprandial state requires coordinated regulation of protein synthesis and folding aligned with changes in lipid metabolism. Here we demonstrate that sensory food perception is sufficient to elicit early activation of hepatic mTOR signaling, Xbp1 splicing, increased expression of ER-stress genes, and phosphatidylcholine synthesis, which translate into a rapid morphological ER remodeling. These responses overlap with those activated during refeeding, where they are maintained and constantly increased upon nutrient supply. Sensory food perception activates POMC neurons in the hypothalamus, optogenetic activation of POMC neurons activates hepatic mTOR signaling and Xbp1 splicing, whereas lack of MC4R expression attenuates these responses to sensory food perception. Chemogenetic POMC-neuron activation promotes sympathetic nerve activity (SNA) subserving the liver, and norepinephrine evokes the same responses in hepatocytes in vitro and in liver in vivo as observed upon sensory food perception. Collectively, our experiments unravel that sensory food perception coordinately primes postprandial liver ER adaption through a melanocortin-SNA-mTOR-Xbp1s axis. VIDEO ABSTRACT.

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 Datum: 2018-11-152018
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: Anderer: 30445039
DOI: 10.1016/j.cell.2018.10.015
ISSN: 1097-4172 (Electronic)0092-8674 (Linking)
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Quelle 1

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Titel: Cell
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 175 (5) Artikelnummer: - Start- / Endseite: 1321 - 1335 e20 Identifikator: -