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  Nucleolar Function in Lifespan Regulation

Tiku, V., & Antebi, A. (2018). Nucleolar Function in Lifespan Regulation. Trends Cell Biol. doi:10.1016/j.tcb.2018.03.007.

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 Creators:
Tiku, Varnesh1, Author           
Antebi, Adam1, Author           
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1Department Antebi - Molecular Genetics of Ageing, Max Planck Institute for Biology of Ageing, Max Planck Society, ou_1942285              

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Free keywords: aging lifespan nucleolus nutrient sensing pathways ribosome biogenesis
 Abstract: The nucleolus is a prominent membraneless organelle residing within the nucleus. The nucleolus has been regarded as a housekeeping structure mainly known for its role in ribosomal RNA (rRNA) production and ribosome assembly. However, accumulating evidence has revealed its functions in numerous cellular processes that control organismal physiology, thereby taking the nucleolus much beyond its conventional role in ribosome biogenesis. Perturbations in nucleolar functions have been associated with severe diseases such as cancer and progeria. Recent studies have also uncovered the role of the nucleolus in development and aging. In this review we discuss major nucleolar functions that impact organismal aging.

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 Dates: 2018-04-272018
 Publication Status: Issued
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 Identifiers: Other: 29779866
DOI: 10.1016/j.tcb.2018.03.007
ISSN: 1879-3088 (Electronic)0962-8924 (Linking)
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Title: Trends Cell Biol
Source Genre: Journal
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