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  Bridge the functional and hemodynamic brain mapping with multi-modal fMRI

Yu, X. (2019). Bridge the functional and hemodynamic brain mapping with multi-modal fMRI. Talk presented at 4th Summer Conference of the European Society for Molecular Imaging: Hot Topics in Imaging Technology (TOPIM TECH 2019): Resolution Revolution. Chania, Greece. 2019-07-01 - 2019-07-06.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-790F-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-7910-2
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Yu, X1, 2, Author              
Affiliations:
1Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528695              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: In this talk, I will introduce the combination of the advanced fMRI method with the emerging neurotechniques to decipher the neuro-glial-vascular (NGV) coupling basis of brain state dynamics. First, we will see through the large voxel acquired from conventional fMRI method to decipher the contribution from distinct vascular components to the fMRI signal. A newly developed single-vessel fMRI method allows identifying the activity-evoked hemodynamic signal propagation through cerebrovasculature in the deep layer cortex, as well as the hippocampal vasculature, with either normal sensory inputs or optogenetic activation. Also, we have developed a line-scanning fMRI method to measure the laminar-fMRI across different cortical regions. Second, we will combine the fMRI with the optical fiber-mediated calcium recordings to decipher the cell-type specific contribution to the fMRI signal from neurons and astrocytes. Meanwhile, we will also show how extracellular glutamate can be recorded simultaneously to mediate NGV interaction. In addition, this multi-modal fMRI setup can be performed with both single-vessel and line-scanning fMRI to better characterize the hemodynamic responses underlying the fMRI signal. Finally, we are going to present how the global fMRI signal fluctuation can be linked to the brain state changes. We merge the pupillometry with the multi-modal fMRI to examine the detailed arousal index by pupil dynamics and fMRI fluctuation. In addition, we also studied the brain state recovery in a brainstem-induced rat coma model with the multi-modal fMRI platform. The series of work leads to the design of MRI-guided robotic arms to guide the deep brain optogenetic stimulation to modify the brain state, as well as an fMRI-based biofeedback control system to optimize the outcome of the treatment.

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 Dates: 2019-07
 Publication Status: Published online
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Title: 4th Summer Conference of the European Society for Molecular Imaging: Hot Topics in Imaging Technology (TOPIM TECH 2019): Resolution Revolution
Place of Event: Chania, Greece
Start-/End Date: 2019-07-01 - 2019-07-06

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Title: 4th Summer Conference of the European Society for Molecular Imaging: Hot Topics in Imaging Technology (TOPIM TECH 2019): Resolution Revolution
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: INV 06-01 Start / End Page: - Identifier: -