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  Hippocampal-midbrain circuit enhances the pleasure of anticipation in the prefrontal cortex

Iigaya, K., Hauser, T., Kurth-Nelson, Z., O’Doherty, J., Dayan, P., & Dolan, R. (2019). Hippocampal-midbrain circuit enhances the pleasure of anticipation in the prefrontal cortex. Poster presented at 4th Multidisciplinary Conference on Reinforcement Learning and Decision Making (RLDM 2019), Montreal, Canada.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-7957-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-DAA8-9
Genre: Poster

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Iigaya, K, Author
Hauser, T, Author
Kurth-Nelson, Z, Author
O’Doherty, JP, Author
Dayan, P1, 2, Author              
Dolan, Rj, Author
Affiliations:
1Department of Computational Neuroscience, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_3017468              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: Whether it is a pleasant dinner or a dream vacation, having something to look forward to is a keystone in building a happy life. Recent studies suggest that reward prediction errors can enhance the pleasure of anticipation. This enhanced anticipation is linked to why people seek information that cannot be acted upon, and is potentially associated with a vulnerability to addiction. However, the neural roots of the pleasure from anticipation are largely unknown. To address this issue, we studied how the brain generates and enhances anticipation, by exposing human participants to a delayed reward decision-making task while imaging their brain activities. Using a computational model of anticipation, we identified a novel anticipatory network consisting of three regions. We found that the ventromedial prefrontal cortex (vmPFC) tracked an anticipation signal, while dopaminergic midbrain responded to an unexpectedly good forecast. We found that hippocampus was coupled both to the vmPFC and to the dopaminergic midbrain, through the model’s computation for boosting anticipation. This result suggests that people might experience greater anticipation when vividly imagining future outcomes. Thus, our findings propose a cognitive circuit for anticipatory value computation, unifying interpretations of separate notions such as risk and delay preference. Our study opens up a new avenue to understanding complex human decisions that are driven by reward anticipation, rather than well-studied reward consumption, and offers a novel intervention target for psychiatric disorders that involve motivation and future rewards.

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 Dates: 2019-07
 Publication Status: Published online
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Title: 4th Multidisciplinary Conference on Reinforcement Learning and Decision Making (RLDM 2019)
Place of Event: Montreal, Canada
Start-/End Date: 2019-07-07 - 2019-07-10

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Title: 4th Multidisciplinary Conference on Reinforcement Learning and Decision Making (RLDM 2019)
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 108 Start / End Page: 122 - 123 Identifier: -