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  Successful Verbal Retrieval in Elderly Subjects Is Related to Concurrent Hippocampal and Posterior Cingulate Activation

Heun, R., Freymann, K., Erb, M., Leube, D., Jessen, F., Kircher, T., et al. (2006). Successful Verbal Retrieval in Elderly Subjects Is Related to Concurrent Hippocampal and Posterior Cingulate Activation. Dementia and Geriatric Cognitive Disorders, 22(2), 165-172. doi:10.1159/000094558.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-8374-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-8375-4
Genre: Journal Article

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https://www.karger.com/Article/Abstract/94558 (Publisher version)
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 Creators:
Heun, R, Author
Freymann, K, Author
Erb, M1, Author              
Leube, DT, Author
Jessen, F, Author
Kircher, TT, Author
Grodd, W1, Author              
Affiliations:
1External Organizations, ou_persistent22              

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 Abstract: Objective: Memory decline and hippocampal atrophy are two major aspects of Alzheimer’s disease. Using a response-related fMRI design, we investigated the relationship between successful verbal retrieval and concurrent cerebral activation in elderly subjects in different stages of cognitive decline. We chose a correlational over the more traditional categorical approach to increase the power of detecting relevant activations. Methods: Eleven subjects with Alzheimer’s disease, 21 elderly subjects with mild cognitive impairment, and 29 age-matched cognitively unimpaired subjects learned 180 nouns. While measuring brain activation with fMRI, the subjects had to classify these 180 learned plus 180 new distractor words as known or new. Response-related fMRI analysis was used to identify cerebral activation by correctly remembered words (hits) that correlated with retrieval success in the whole group. Results: Successful verbal retrieval was significantly correlated with concurrent activation of the left hippocampus and posterior cingulate gyrus. Conclusion: The study confirms the importance of adequate hippocampal function for successful verbal retrieval in the elderly. In addition, our study supports connectivity studies indicating a functional relationship between the hippocampus and the posterior cingulate gyrus during successful verbal retrieval in the elderly in different stages of cognitive decline.

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 Dates: 2006-08
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1159/000094558
 Degree: -

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Title: Dementia and Geriatric Cognitive Disorders
  Other : Dement. Geriatr. Cogn. Disord.
Source Genre: Journal
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Publ. Info: Basel : Karger
Pages: - Volume / Issue: 22 (2) Sequence Number: - Start / End Page: 165 - 172 Identifier: ISSN: 1420-8008
CoNE: https://pure.mpg.de/cone/journals/resource/954926994173