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  Combined Behavioral and c-Fos Studies Elucidate the Vital Role of Sodium for Odor Detection

Weiler, E., Deutsch, S., & Apfelbach, R. (2006). Combined Behavioral and c-Fos Studies Elucidate the Vital Role of Sodium for Odor Detection. Chemical Senses, 31(7), 641-647. doi:10.1093/chemse/bjl004.

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Weiler, E1, Author              
Deutsch, S, Author
Apfelbach, R, Author
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1External Organizations, ou_persistent22              

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 Abstract: Salt, known as taste quality, is generally neglected in olfaction, although the olfactory sensory neurons stretch into the salty nasal mucus covering the olfactory epithelium (OE). Using a psychophysical approach, we directly and functionally demonstrate in the awake rat for a variety of structurally diverse odorants that sodium is a critical factor for olfactory perception and sensitivity, both very important components of mammalian communication and sexual behavior. Bathing the olfactory mucus with an iso-osmotic sodium-free buffer solution results in severe deficits in odorant detection. However, sensitivity returns fully within a few hours, indicating continuous mucus production. In the presence of sodium in the mucus covering the OE, all odorants induce odorant-specific c-Fos expression in the olfactory bulb. Yet, if sodium is absent in the mucus, no c-Fos expression is induced as demonstrated for n-octanal. Our noninvasive approach to induce anosmia in mammals here presented—which is fully reversible within hours—opens new possibilities to study the functions of olfactory communication in awake animals.

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 Dates: 2006-09
 Publication Status: Published in print
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 Identifiers: DOI: 10.1093/chemse/bjl004
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Title: Chemical Senses
Source Genre: Journal
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Publ. Info: Oxford : Oxford University Press [etc.]
Pages: - Volume / Issue: 31 (7) Sequence Number: - Start / End Page: 641 - 647 Identifier: ISSN: 0379-864X
CoNE: https://pure.mpg.de/cone/journals/resource/954928560444