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  Sobremesa L-type amino acid transporter expressed in Glia is essential for proper timing of development and brain growth

Galagovsky, D., Depetris-Chauvin, A., Manière, G., Geillon, F., Berthelot-Grosjean, M., Noirot, E., et al. (2018). Sobremesa L-type amino acid transporter expressed in Glia is essential for proper timing of development and brain growth. Cell Reports, 24(12), 3156-3166. doi:10.1016/j.celrep.2018.08.067.

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http://dx.doi.org/10.1016/j.celrep.2018.08.067 (Publisher version)
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 Creators:
Galagovsky, Diego1, Author              
Depetris-Chauvin, Ana2, 3, Author              
Manière, Gérard , Author
Geillon, Flore, Author
Berthelot-Grosjean, Martine, Author
Noirot, Elodie, Author
Alves, Georges, Author
Grosjean, Yael, Author
Affiliations:
1External Organizations, ou_persistent22              
2Department of Evolutionary Neuroethology, Prof. B. S. Hansson, MPI for Chemical Ecology, Max Planck Society, ou_421894              
3Research Group Dr. S. Sachse, Olfactory Coding, MPI for Chemical Ecology, Max Planck Society, ou_421914              

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 Abstract: In Drosophila, ecdysone hormone levels determine the timing of larval development. Its production is regulated by the stereotypical rise in prothoracicotropic hormone (PTTH) levels. Additionally, ecdysone levels can also be modulated by nutrition (specifically by amino acids) through their action on Drosophila insulin-like peptides (Dilps). Moreover, in glia, amino-acid-sensitive production of Dilps regulates brain development. In this work, we describe the function of an SLC7 amino acid transporter, Sobremesa (Sbm). Larvae with reduced Sbm levels in glia remain in third instar for an additional 24 hr. These larvae show reduced brain growth with increased body size but do not show reduction in insulin signaling or production. Interestingly, Sbm downregulation in glia leads to reduced Ecdysone production and a surprising delay in the rise of PTTH levels. Our work highlights Sbm as a modulator of both brain development and the timing of larval development via an amino-acid-sensitive and Dilp-independent function of glia.

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 Dates: 2018-09-18
 Publication Status: Published in print
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 Identifiers: Other: HAN322
DOI: 10.1016/j.celrep.2018.08.067
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Title: Cell Reports
Source Genre: Journal
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Publ. Info: Maryland Heights, MO : Cell Press
Pages: - Volume / Issue: 24 (12) Sequence Number: - Start / End Page: 3156 - 3166 Identifier: ISSN: 2211-1247
CoNE: https://pure.mpg.de/cone/journals/resource/2211-1247