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  Sobremesa L-type amino acid transporter expressed in Glia is essential for proper timing of development and brain growth

Galagovsky, D., Depetris-Chauvin, A., Manière, G., Geillon, F., Berthelot-Grosjean, M., Noirot, E., et al. (2018). Sobremesa L-type amino acid transporter expressed in Glia is essential for proper timing of development and brain growth. Cell Reports, 24(12), 3156-3166. doi:10.1016/j.celrep.2018.08.067.

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http://dx.doi.org/10.1016/j.celrep.2018.08.067 (Publisher version)
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 Creators:
Galagovsky, Diego1, Author           
Depetris-Chauvin, Ana2, 3, Author           
Manière, Gérard , Author
Geillon, Flore, Author
Berthelot-Grosjean, Martine, Author
Noirot, Elodie, Author
Alves, Georges, Author
Grosjean, Yael, Author
Affiliations:
1External Organizations, ou_persistent22              
2Department of Evolutionary Neuroethology, Prof. B. S. Hansson, MPI for Chemical Ecology, Max Planck Society, ou_421894              
3Research Group Dr. S. Sachse, Olfactory Coding, MPI for Chemical Ecology, Max Planck Society, ou_421914              

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 Abstract: In Drosophila, ecdysone hormone levels determine the timing of larval development. Its production is
regulated by the stereotypical rise in prothoracicotropic
hormone (PTTH) levels. Additionally, ecdysone
levels can also be modulated by nutrition (specifically
by amino acids) through their action on Drosophila
insulin-like peptides (Dilps). Moreover, in glia,
amino-acid-sensitive production of Dilps regulates
brain development. In this work, we describe the
function of an SLC7 amino acid transporter, Sobremesa
(Sbm). Larvae with reduced Sbm levels in glia
remain in third instar for an additional 24 hr. These
larvae show reduced brain growth with increased
body size but do not show reduction in insulin
signaling or production. Interestingly, Sbm downregulation
in glia leads to reduced Ecdysone production
and a surprising delay in the rise of PTTH levels.
Our work highlights Sbm as a modulator of both brain
development and the timing of larval development
via an amino-acid-sensitive and Dilp-independent function of glia.

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 Dates: 2018-09-18
 Publication Status: Issued
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 Identifiers: Other: HAN322
DOI: 10.1016/j.celrep.2018.08.067
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Title: Cell Reports
Source Genre: Journal
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Publ. Info: Maryland Heights, MO : Cell Press
Pages: - Volume / Issue: 24 (12) Sequence Number: - Start / End Page: 3156 - 3166 Identifier: ISSN: 2211-1247
CoNE: https://pure.mpg.de/cone/journals/resource/2211-1247