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  Higher cardiovascular fitness level is associated with lower cerebrovascular reactivity and perfusion in healthy older adults

Intzandt, B., Sabra, D., Foster, C., Desjardins-Crépeau, L., Hoge, R. D., Steele, C., et al. (2019). Higher cardiovascular fitness level is associated with lower cerebrovascular reactivity and perfusion in healthy older adults. Journal of Cerebral Blood Flow and Metabolism. doi:10.1177/0271678X19862873.

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Intzandt, Brittany 1, Author
Sabra, Dalia 1, Author
Foster, Catherine 1, Author
Desjardins-Crépeau, Laurence 1, Author
Hoge, Richard D.1, Author
Steele, Christopher1, 2, Author              
Bherer, Louis1, Author
Gauthier, Claudine J.1, Author
1External Organizations, ou_persistent22              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              


Free keywords: Aging; cerebrovascular reactivity; fitness; MRI; perfusion-weighted imaging
 Abstract: Aging is accompanied by vascular and structural changes in the brain, which include decreased grey matter volume (GMV), cerebral blood flow (CBF), and cerebrovascular reactivity (CVR). Enhanced fitness in aging has been related to preservation of GMV and CBF, and in some cases CVR, although there are contradictory relationships reported between CVR and fitness. To gain a better understanding of the complex interplay between fitness and GMV, CBF and CVR, the present study assessed these factors concurrently. Data from 50 participants, aged 55 to 72, were used to derive GMV, CBF, CVR and VO2peak. Results revealed that lower CVR was associated with higher VO2peak throughout large areas of the cerebral cortex. Within these regions lower fitness was associated with higher CBF and a faster hemodynamic response to hypercapnia. Overall, our results indicate that the relationships between age, fitness, cerebral health and cerebral hemodynamics are complex, likely involving changes in chemosensitivity and autoregulation in addition to changes in arterial stiffness. Future studies should collect other physiological outcomes in parallel with quantitative imaging, such as measures of chemosensitivity and autoregulation, to further understand the intricate effects of fitness on the aging brain, and how this may bias quantitative measures of cerebral health.


Language(s): eng - English
 Dates: 2018-12-102019-06-022019-07-25
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1177/0271678X19862873
PMID: 31342831
Other: Epub ahead of print
 Degree: -



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Project information

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Project name : -
Grant ID : MOP 84378
Funding program : Banting and Best Scholarship
Funding organization : Canadian Institutes of Health Research (CIHR)
Project name : -
Grant ID : 17380
Funding program : Leaders Opportunity Fund
Funding organization : Canada Foundation for Innovation
Project name : -
Grant ID : PSR-SIIRI-239
Funding program : -
Funding organization : Ministère du développement économique, de l'innovation et de l'exportation
Project name : -
Grant ID : R0018142 ; RGPIN 2015-04665
Funding program : -
Funding organization : Canadian National Sciences and Engineering Research Council
Project name : -
Grant ID : -
Funding program : New Investigator Award
Funding organization : Heart and Stroke Foundation of Canada
Project name : -
Grant ID : -
Funding program : -
Funding organization : Michal and Renata Hornstein Chair in Cardiovascular Imaging

Source 1

Title: Journal of Cerebral Blood Flow and Metabolism
Source Genre: Journal
Publ. Info: New York : Lippincott Williams & Wilkins
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 0271-678X
CoNE: https://pure.mpg.de/cone/journals/resource/954925503202