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  Interactions of hepatotoxic agents with proteins and subcellular structures

Faulstich, H. (1980). Interactions of hepatotoxic agents with proteins and subcellular structures. Toxicology, 18(3), 205-211. doi:10.1016/0300-483X(80)90065-7.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-8654-6 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-8655-5
Genre: Journal Article

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Toxicology_18_1980_205.pdf (Any fulltext), 717KB
 
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 Creators:
Faulstich, Heinz1, Author              
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1Department of Molecular Cell Research, Max Planck Institute for Medical Research, Max Planck Society, ou_1497703              

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 Abstract: Two proteins with high affinity for amatoxins have been characterized in calf thymus nucleic, the RNA-polymerase II (or B) and a 100 K protein of unknown function. Most of the toxic effects of amatoxins are based on the inhibited synthesis of mRNA. The 100 K protein may be involved in functions of cytokinesis as suggested by experiments with PtK1 cells and a fluorescent labelled amatoxin. The molecular toxicity of phallotoxins can be understood in terms of their affinity for actin. By interaction with rabbit muscle actin the concentration of action monomers is decreased. In hepatocytes, the phallotoxins change the structure of the microfilamentous web.

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Language(s): eng - English
 Dates: 2002-11-141980
 Publication Status: Published in print
 Pages: 7
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/0300-483X(80)90065-7
 Degree: -

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Title: Toxicology
  Other : Toxicology
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 18 (3) Sequence Number: - Start / End Page: 205 - 211 Identifier: ISSN: 0300-483X
CoNE: https://pure.mpg.de/cone/journals/resource/954925507335