English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  The impact of ischemic stroke on connectivity gradients

Bayrak, S., Khalil, A., Villringer, K., Fiebach, J., Villringer, A., Margulies, D. S., et al. (2019). The impact of ischemic stroke on connectivity gradients. NeuroImage: Clinical, 24: 101947. doi:10.1016/j.nicl.2019.101947.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0004-8DFC-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-E5B3-F
Genre: Journal Article

Files

show Files
hide Files
:
Bayrak_2019.pdf (Publisher version), 2MB
Name:
Bayrak_2019.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Bayrak, Seyma1, 2, Author              
Khalil, Ahmed1, 3, 4, Author              
Villringer, Kersten3, Author
Fiebach, Jochen3, Author
Villringer, Arno1, 2, 3, 4, Author              
Margulies, Daniel S.5, Author              
Ovadia-Caro, Smadar1, 4, 6, Author              
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
3Center for Stroke Research, Charité University Medicine Berlin, Germany, ou_persistent22              
4Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              
5Centre National de la Recherche Scientifique, Paris, France, ou_persistent22              
6Department of Neurology, Charité University Medicine Berlin, Germany, ou_persistent22              

Content

show
hide
Free keywords: Connectivity gradients; Intrinsic functional connectivity; Diaschisis; Resting-state fMRI; Connectome; Diffusion embedding
 Abstract: The functional organization of the brain can be represented as a low-dimensional space that reflects its macroscale hierarchy. The dimensions of this space, described as connectivity gradients, capture the similarity of areas' connections along a continuous space. Studying how pathological perturbations with known effects on functional connectivity affect these connectivity gradients provides support for their biological relevance. Previous work has shown that localized lesions cause widespread functional connectivity alterations in structurally intact areas, affecting a network of interconnected regions. By using acute stroke as a model of the effects of focal lesions on the connectome, we apply the connectivity gradient framework to depict how functional reorganization occurs throughout the brain, unrestricted by traditional definitions of functional network boundaries. We define a three-dimensional connectivity space template based on functional connectivity data from healthy controls. By projecting lesion locations into this space, we demonstrate that ischemic strokes result in dimension-specific alterations in functional connectivity over the first week after symptom onset. Specifically, changes in functional connectivity were captured along connectivity Gradients 1 and 3. The degree of functional connectivity change was associated with the distance from the lesion along these connectivity gradients (a measure of functional similarity) regardless of the anatomical distance from the lesion. Together, these results provide support for the biological validity of connectivity gradients and suggest a novel framework to characterize connectivity alterations after stroke.

Details

show
hide
Language(s): eng - English
 Dates: 2019-07-082019-04-162019-07-172019-07-19
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.nicl.2019.101947
PMID: 31376644
PMC: PMC6676042
Other: Epub ahead of print
 Degree: -

Event

show

Legal Case

show

Project information

show hide
Project name : -
Grant ID : 01EO01301 ; 01EO0801
Funding program : -
Funding organization : German Federal Ministry of Education and Research (BMBF)
Project name : Efficacy and safety of MRI-based thrombolysis in wake-up stroke: a randomised, double-blind, placebo-controlled trial / WAKE-UP
Grant ID : 278276
Funding program : Funding Programme 7
Funding organization : European Commission (EC)
Project name : -
Grant ID : EDP-2016-318
Funding program : -
Funding organization : Einstein Foundation Berlin

Source 1

show
hide
Title: NeuroImage: Clinical
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Elsevier
Pages: - Volume / Issue: 24 Sequence Number: 101947 Start / End Page: - Identifier: ISSN: 2213-1582
CoNE: https://pure.mpg.de/cone/journals/resource/2213-1582