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  Mapping a single-molecule folding process onto a topological space

Heidari, M., Satarifard, V., & Mashagh, A. (2019). Mapping a single-molecule folding process onto a topological space. Physical Chemistry Chemical Physics, 21(36), 20338-20345. doi:10.1039/C9CP03175H.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-8A98-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-D5C8-A
Genre: Journal Article

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 Creators:
Heidari, Maziar, Author
Satarifard, Vahid1, Author              
Mashagh, Alireza, Author
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1Andrea Grafmüller, Theorie & Bio-Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863323              

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 Abstract: Physics of protein folding has been dominated by conceptual frameworks including nucleation-propagation mechanism and the diffusion-collision model, none address topological properties of a chain during a folding process. Single-molecule interrogation of folded biomolecules has enabled real-time monitoring of the folding processes at an unprecedented resolution. Despite these advances, the topology landscape has not been fully mapped for any chain. Using a novel circuit topology approach, we map the topology landscape of a model polymeric chain. Inspired by single-molecule mechanical interrogation studies, we restrained the ends of a chain and followed fold nucleation dynamics. We find that, before the nucleation, transient local entropic loops dominate. Although the nucleation length of globules is dependent on the cohesive interaction, the ultimate topological states of the collapsed polymer are largely independent of the interaction but depend on the speed of the folding process. After the nucleation, transient topological rearrangements are observed that converge to a steady-state, where the fold grows in a self-similar manner.

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Language(s): eng - English
 Dates: 2019-08-222019
 Publication Status: Published in print
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 Identifiers: DOI: 10.1039/C9CP03175H
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Title: Physical Chemistry Chemical Physics
  Abbreviation : Phys. Chem. Chem. Phys.
Source Genre: Journal
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Publ. Info: Cambridge, England : Royal Society of Chemistry
Pages: - Volume / Issue: 21 (36) Sequence Number: - Start / End Page: 20338 - 20345 Identifier: ISSN: 1463-9076