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  MgO nanoparticles coated with polyethylene glycol as carrier for 2-Methoxyestradiol anticancer drug

Alfaro, A., León, A., Guajardo-Correa, E., Reúquen, P., Torres, F., Mery, M., et al. (2019). MgO nanoparticles coated with polyethylene glycol as carrier for 2-Methoxyestradiol anticancer drug. PLoS One, 14(8): e0214900, pp. 1-12. doi:10.1371/journal.pone.0214900.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-8CD8-B Version Permalink: http://hdl.handle.net/21.11116/0000-0004-8CE5-C
Genre: Journal Article

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 Creators:
Alfaro, Aline1, Author
León, Andrea2, Author              
Guajardo-Correa, Emanuel1, Author
Reúquen, Patricia1, Author
Torres, Francisco1, Author
Mery, Mario1, Author
Segura, Rodrigo1, Author
Zapata, Paula A.1, Author
Orihuela, Pedro A.1, Author
Affiliations:
1External Organizations, ou_persistent22              
2Physics of Quantum Materials, Max Planck Institute for Chemical Physics of Solids, Max Planck Society, ou_1863462              

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 Abstract: Novel Magnesium Oxide (MgO) nanoparticles (NPs) modified with the polymer polyethylene glycol (PEG) were synthesized as carrier for the anticancer drug 2-Methoxyestradiol (2ME) to improve its clinical application. The functionalized NPs were characterized by Infrared spectroscopy with Fourier transform to elucidate the vibration modes of this conjugate, indicating the formation of the MgO-PEG-2ME nanocomposite. The studies of absorption and liberation determined that MgO-PEG-2ME NPs incorporated 98.51 of 2ME while liberation of 2ME was constant during 7 days at pH 2, 5 and 7.35. Finally, the MgO-PEG-2ME NPs decreased the viability of the prostate cancer cell line LNCap suggesting that this nanocomposite is suitable as a drug delivery system for anticancer prostate therapy. © 2019 Alfaro et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Language(s): eng - English
 Dates: 2019-08-152019-08-15
 Publication Status: Published in print
 Pages: -
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 Rev. Method: -
 Identifiers: DOI: 10.1371/journal.pone.0214900
BibTex Citekey: Alfaro2019
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Title: PLoS One
Source Genre: Journal
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Publ. Info: San Francisco, CA : Public Library of Science
Pages: - Volume / Issue: 14 (8) Sequence Number: e0214900 Start / End Page: 1 - 12 Identifier: ISSN: 1932-6203
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000277850