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  Brain maturation is associated with increasing tissue stiffness and decreasing tissue fluidity

Guo, J., Bertalan, G., Meierhofer, D., Klein, C., Schreyer, S., Steiner, B., et al. (2019). Brain maturation is associated with increasing tissue stiffness and decreasing tissue fluidity. Acta Biomaterialia, pii: S1742-7061(19)30592-6. doi:10.1016/j.actbio.2019.08.036.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-8D07-6 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-8D08-5
Genre: Journal Article

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 Creators:
Guo, Jing , Author
Bertalan, Gergely , Author
Meierhofer, David1, Author              
Klein, Charlotte , Author
Schreyer, Stefanie , Author
Steiner, Barbara , Author
Wang, Shuangqing , Author
Vieira da Silva, Rafaela , Author
Infante-Duarte, Carmen , Author
Koch, Stefan, Author
Boehm-Sturm, Philipp , Author
Braun, Jürgen , Author
Sack, Ingolf , Author
Affiliations:
1Mass Spectrometry (Head: David Meierhofer), Scientific Service (Head: Christoph Krukenkamp), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479669              

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Free keywords: MR elastography; brain tissue; maturation; proteomics analysis; viscoelasticity
 Abstract: Biomechanical cues guide proliferation, growth and maturation of neurons. Yet the molecules that shape the brain's biomechanical properties are unidentified and the relationship between neural development and viscoelasticity of brain tissue remains elusive. Here we combined novel in-vivo tomoelastography and ex-vivo proteomics to investigate whether viscoelasticity of the mouse brain correlates with protein alterations within the critical phase of brain maturation. For the first time, high-resolution atlases of viscoelasticity of the mouse brain were generated, revealing that (i)brain stiffness increased alongside progressive accumulation of microtubular structures, myelination, cytoskeleton linkage and cell-matrix attachment, and that (ii) viscosity-related tissue fluidity decreased alongside downregulated actin crosslinking and axonal organization. Taken together, our results show that brain maturation is associated with a shift of brain mechanical properties towards a more solid-rigid behavior consistent with reduced tissue fluidity. This shift appears to be driven by several molecular processes associated with myelination, cytoskeletal crosslinking and axonal organization.

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Language(s): eng - English
 Dates: 2019-08-212019-08-23
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1016/j.actbio.2019.08.036
PMID: 31449927
 Degree: -

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Title: Acta Biomaterialia
  Other : Acta Biomater.
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: - Sequence Number: pii: S1742-7061(19)30592-6 Start / End Page: - Identifier: ISSN: 1742-7061
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000017060