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  Brain structural differences in monozygotic twins discordant for body mass index

Weise, C., Bachmann, T., & Pleger, B. (2019). Brain structural differences in monozygotic twins discordant for body mass index. NeuroImage, 201: 116006. doi:10.1016/j.neuroimage.2019.07.019.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-9189-D Version Permalink: http://hdl.handle.net/21.11116/0000-0004-D7E6-6
Genre: Journal Article

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 Creators:
Weise, Christopher1, Author
Bachmann, Tobias1, Author
Pleger, Burkhard1, 2, Author              
Affiliations:
1External Organizations, ou_persistent22              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              

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 Abstract: Background:Substantial efforts have been made to investigate the neurobiological underpinnings of human obesity with a number of studies indicating a profoundinfluence of increased body weight on brain structure. Although body weight is known to be highly heritable, uncertainty remains regarding the respective contri-bution of genetic and environmental influences.Methods:In this study we used structural magnetic resonance imaging (MRI) data from the Human Connectome Project (HCP). Voxel-based morphometry (VBM) wasapplied to study BMI-associated differences in gray matter volume (GMV) within monozygotic (MZ) twin pairs discordant for BMI (ΔBMI>2.5 kg*m2,n¼68 pairs).In addition, we investigated the relationship ofΔBMI (entire range) with GMV differences within the entire sample of MZ twin pairs (n¼153 pairs).Results:Analyses of BMI discordant twin pairs yielded less GMV in heavier twin siblings (p<0.05 FWETFCE; pairedt-Test) within the occipital and cerebellar cortex, theprefrontal cortex and the bilateral striatum including the nucleus accumbens. A highly converging pattern was found in regression analyses across the entire sample ofMZ twin pairs, withΔBMI being associated with less GMV in heavier MZ twins.Conclusion:While MZ twins share the same genetic background, ourfindings indicate that non-genetic influences and the mere presence of a higher BMI constituterelevant factors in the context of body weight related structural brain alterations.

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Language(s): eng - English
 Dates: 2019-07-012019-03-072019-07-082019-07-092019-11-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.neuroimage.2019.07.019
PMID: 31299367
Other: Epub ahead of print
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Project name : -
Grant ID : 01E01001
Funding program : -
Funding organization : IFB Adiposity Diseases, German Federal Ministry of Education and Research (BMBF)
Project name : Kompetenzcluster für Ernährung und kardiovaskuläre Gesundheit / nutriCARD
Grant ID : 01EA1808B
Funding program : -
Funding organization : German Federal Ministry of Education and Research (BMBF)
Project name : Obesity Mechanisms / SFB 1052
Grant ID : -
Funding program : -
Funding organization : German Research Foundation (DFG)

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Title: NeuroImage
Source Genre: Journal
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Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 201 Sequence Number: 116006 Start / End Page: - Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166