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  Divergent default mode network connectivity during social perception in 22q11.2 deletion syndrome

Dubourg, L., Vrticka, P., Pouillard, V., Eliez, S., & Schneider, M. (2019). Divergent default mode network connectivity during social perception in 22q11.2 deletion syndrome. Psychiatry Research: Neuroimaging, 291, 9-17. doi:10.1016/j.pscychresns.2019.07.004.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-9186-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-9187-F
Genre: Journal Article

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 Creators:
Dubourg, Lydia1, Author
Vrticka, Pascal2, Author              
Pouillard, Virginie1, Author
Eliez, Stephan1, Author
Schneider, Maude1, Author
Affiliations:
1External Organizations, ou_persistent22              
2Department Social Neuroscience, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634552              

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Free keywords: 22q11.2 deletion syndrome; Default mode network; Functional connectivity; Social perception
 Abstract: AIM: The 22q11.2 deletion (22q11DS) syndrome is a neurogenetic condition marked by social dysfunction. A major network involved in social cognition is the default mode network (DMN). To date, no study has investigated DMN functional connectivity during socio-cognitive paradigms in 22q11DS. METHOD: We used the psychophysiological analysis (PPI) to investigate functional connectivity of the DMN during social perception in 22 participants with 22q11DS and 22 healthy controls. Association between DMN connectivity and prodromal symptoms was also examined. RESULTS: 22q11DS patients exhibited stronger connectivity between the inferior parietal lobule (IPL) and the posterior cingulate cortex (PCC)/precuneus as well as lower connectivity between the precuneus and middle/superior frontal regions compared to controls. Association between IPL-PCC/precuneus connectivity and negative symptoms was also found in individuals with 22q11DS. CONCLUSION: Our results point to (1) divergent DMN connectivity in patients with 22q11DS compared to controls; (2) association between DMN connectivity and negative symptom severity in patients. Results support the role of the DMN in social deficits of the 22q11DS population.

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Language(s): eng - English
 Dates: 2019-07-092019-01-042019-07-122019-07-152019-09-30
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.pscychresns.2019.07.004
PMID: 31344628
Other: Epub 2019
 Degree: -

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Title: Psychiatry Research: Neuroimaging
  Other : Psychiatry Res. Neuroimaging
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Elsevier
Pages: - Volume / Issue: 291 Sequence Number: - Start / End Page: 9 - 17 Identifier: ISSN: 0925-4927
CoNE: https://pure.mpg.de/cone/journals/resource/954925566740