Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT
Zur Ablage hinzufügen
 Lokale TagsFreigabegeschichteDetailsÜbersicht
  Epigenetic modification of the oxytocin receptor gene is associated with emotion processing in the infant brain

Krol, K. M., Puglia, M. H., Morris, J. P., Connelly, J. J., & Grossmann, T. (2019). Epigenetic modification of the oxytocin receptor gene is associated with emotion processing in the infant brain. Developmental Cognitive Neuroscience, 37: 100648. doi:10.1016/j.dcn.2019.100648.

Item is

 

einblenden: alle ausblenden: alle

Basisdaten

einblenden: ausblenden:
Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-0004-91A5-D Versions-Permalink: https://hdl.handle.net/21.11116/0000-0004-E483-6
Genre: Zeitschriftenartikel

Dateien

einblenden: Dateien
ausblenden: Dateien
:
Krol_2019.pdf (Verlagsversion), 2MB
Öffnen   Speichern
Datei-Permalink:
https://hdl.handle.net/21.11116/0000-0004-91A7-B
Name:
Krol_2019.pdf
Beschreibung:
-
OA-Status:
Sichtbarkeit:
Öffentlich
MIME-Typ / Prüfsumme:
application/pdf / [MD5]
Technische Metadaten:
Öffnen
Copyright Datum:
-
Copyright Info:
-
Lizenz:
-

Externe Referenzen

einblenden:

Urheber

einblenden:
ausblenden:
 Urheber:
Krol, K. M.1, 2, Autor           
Puglia, Meghan H.1, Autor
Morris, James P.1, Autor
Connelly, Jessica J.1, Autor
Grossmann, Tobias1, 2, Autor           
Affiliations:
1Department of Psychology, University of Virginia, Charlottesville, VA, USA, ou_persistent22              
2Max Planck Research Group Early Social Development, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_1356545              

Inhalt

einblenden:
ausblenden:
Schlagwörter: DNA methylation; Emotion; Epigenetics; Infancy; Inferior frontal cortex; Oxytocin; fNIRS
 Zusammenfassung: The neural capacity to discriminate between emotions emerges early in development, though little is known about specific factors that contribute to variability in this vital skill during infancy. In adults, DNA methylation of the oxytocin receptor gene (OXTRm) is an epigenetic modification that is variable, predictive of gene expression, and has been linked to autism spectrum disorder and the neural response to social cues. It is unknown whether OXTRm is variable in infants, and whether it is predictive of early social function. Implementing a developmental neuroimaging epigenetics approach in a large sample of infants (N = 98), we examined whether OXTRm is associated with neural responses to emotional expressions. OXTRm was assessed at 5 months of age. At 7 months of age, infants viewed happy, angry, and fearful faces while functional near-infrared spectroscopy was recorded. We observed that OXTRm shows considerable variability among infants. Critically, infants with higher OXTRm show enhanced responses to anger and fear and attenuated responses to happiness in right inferior frontal cortex, a region implicated in emotion processing through action-perception coupling. Findings support models emphasizing oxytocin's role in modulating neural response to emotion and identify OXTRm as an epigenetic mark contributing to early brain function.

Details

einblenden:
ausblenden:
Sprache(n): eng - English
 Datum: 2019-04-182018-08-242019-04-182019-04-26
 Publikationsstatus: Online veröffentlicht
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1016/j.dcn.2019.100648
PMID: 31125951
Anderer: Epub 2019
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden: ausblenden:
Projektname : -
Grant ID : -
Förderprogramm : -
Förderorganisation : Max Planck Society
Projektname : -
Grant ID : -
Förderprogramm : -
Förderorganisation : University of Virginia
Projektname : -
Grant ID : -
Förderprogramm : International Max Planck Research School Scholarship
Förderorganisation : International Max Planck Research School on Neuroscience of Communication: Function, Structure, and Plasticity (IMPRS NeuroCom)
Projektname : -
Grant ID : -
Förderprogramm : Research Training in Neuroendocrinology Fellowship (NIH NRSA T32)
Förderorganisation : National Institutes of Health (NIH)
Projektname : -
Grant ID : -
Förderprogramm : Hartwell Biomedical Research Fellowship
Förderorganisation : The Hartwell Foundation
Projektname : Examining an Epigenetic Biomarker of Social Perception
Grant ID : 1228522
Förderprogramm : -
Förderorganisation : National Science Foundation (NSF)
Projektname : Epigenetic influences on the early development of social brain functions
Grant ID : 1729289
Förderprogramm : -
Förderorganisation : National Science Foundation (NSF)

Quelle 1

einblenden:
ausblenden:
Titel: Developmental Cognitive Neuroscience
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Amsterdam : Elsevier
Seiten: - Band / Heft: 37 Artikelnummer: 100648 Start- / Endseite: - Identifikator: ISSN: 1878-9293
CoNE: https://pure.mpg.de/cone/journals/resource/1878-9293