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  Live-cell STED nanoscopy of mitochondrial cristae.

Stephan, T., Roesch, A., Riedel, D., & Jakobs, S. (2019). Live-cell STED nanoscopy of mitochondrial cristae. Scientific Reports, 9(1): 12419. doi:10.1038/s41598-019-48838-2 Free full text.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-96AF-E Version Permalink: http://hdl.handle.net/21.11116/0000-0004-96B8-3
Genre: Journal Article

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 Creators:
Stephan, T.1, Author              
Roesch, A.1, Author              
Riedel, D.2, Author              
Jakobs, S.1, Author              
Affiliations:
1Research Group of Mitochondrial Structure and Dynamics, MPI for biophysical chemistry, Max Planck Society, ou_578566              
2Facility for Electron Microscopy, MPI for biophysical chemistry, Max Planck Society, ou_578615              

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 Abstract: Mitochondria are highly dynamic organelles that exhibit a complex inner architecture. They exhibit a smooth outer membrane and a highly convoluted inner membrane that forms invaginations called cristae. Imaging cristae in living cells poses a formidable challenge for super-resolution light microscopy. Relying on a cell line stably expressing the mitochondrial protein COX8A fused to the SNAP-tag and using STED (stimulated emission depletion) nanoscopy, we demonstrate the visualization of cristae dynamics in cultivated human cells. We show that in human HeLa cells lamellar cristae are often arranged in groups separated by voids that are generally occupied by mitochondrial nucleoids.

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Language(s): eng - English
 Dates: 2019-08-272019
 Publication Status: Published in print
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 Rev. Method: Peer
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Title: Scientific Reports
Source Genre: Journal
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Pages: 6 Volume / Issue: 9 (1) Sequence Number: 12419 Start / End Page: - Identifier: -