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  Hippocampus, retrosplenial and parahippocampal cortices encode multicompartment 3D space in a hierarchical manner

Kim, M., & Maguire, E. (2018). Hippocampus, retrosplenial and parahippocampal cortices encode multicompartment 3D space in a hierarchical manner. Cerebral Cortex, 28(5), 1898-1909. doi:10.1093/cercor/bhy054.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-9C01-B Version Permalink: http://hdl.handle.net/21.11116/0000-0004-D81E-8
Genre: Journal Article

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 Creators:
Kim, Misun1, Author              
Maguire, Eleanor1, Author
Affiliations:
1Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, United Kingdom, ou_persistent22              

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Free keywords: 3D space; Compartmentalized; fMRI; Hippocampus; Isotropic
 Abstract: Humans commonly operate within 3D environments such as multifloor buildings and yet there is a surprising dearth of studies that have examined how these spaces are represented in the brain. Here, we had participants learn the locations of paintings within a virtual multilevel gallery building and then used behavioral tests and fMRI repetition suppression analyses to investigate how this 3D multicompartment space was represented, and whether there was a bias in encoding vertical and horizontal information. We found faster response times for within-room egocentric spatial judgments and behavioral priming effects of visiting the same room, providing evidence for a compartmentalized representation of space. At the neural level, we observed a hierarchical encoding of 3D spatial information, with left anterior hippocampus representing local information within a room, while retrosplenial cortex, parahippocampal cortex, and posterior hippocampus represented room information within the wider building. Of note, both our behavioral and neural findings showed that vertical and horizontal location information was similarly encoded, suggesting an isotropic representation of 3D space even in the context of a multicompartment environment. These findings provide much-needed information about how the human brain supports spatial memory and navigation in buildings with numerous levels and rooms.

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Language(s): eng - English
 Dates: 2018-02-162017-06-282018-02-202018-03-152018-05
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1093/cercor/bhy054
PMID: 29554231
PMC: PMC5907342
 Degree: -

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Project name : -
Grant ID : 101759/Z/13/Z ; 203147/Z/16/Z ; 102263/Z/13/Z
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Funding organization : Wellcome Trust
Project name : -
Grant ID : -
Funding program : Samsung Scholarship
Funding organization : Samsung

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Title: Cerebral Cortex
Source Genre: Journal
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Publ. Info: New York, NY : Oxford University Press
Pages: - Volume / Issue: 28 (5) Sequence Number: - Start / End Page: 1898 - 1909 Identifier: ISSN: 1047-3211
CoNE: https://pure.mpg.de/cone/journals/resource/954925592440