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  A biophysical model of iron-induced relaxation in human substantia nigra for early stage parkinson diagnostic

Brammerloh, M., Lange, C., Reinert, T., Jäger, C., Gavriilidis, F., Pine, K., et al. (2019). A biophysical model of iron-induced relaxation in human substantia nigra for early stage parkinson diagnostic. In Proceedings of the ISMRM 27th Annual Meeting & Exhibition.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-9C14-6 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-9C15-5
Genre: Meeting Abstract

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 Creators:
Brammerloh, Malte1, 2, Author              
Lange, Charlotte2, 3, Author
Reinert, Tilo1, 2, Author              
Jäger, Carsten1, Author              
Gavriilidis, Filippos1, Author              
Pine, Kerrin1, Author              
Weigelt, Isabel, Author
Trampel, Robert4, Author              
Reimer, Enrico4, Author              
Morawski, Markus3, Author              
Arendt, Thomas3, Author
Weiskopf, Nikolaus1, 2, Author              
Kirilina, Evgeniya1, 5, Author              
Affiliations:
1Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
2Faculty of Physics and Earth Sciences, Leipzig University, Leipzig, Germany, ou_persistent22              
3Paul Flechsig Institute of Brain Research, Leipzig, Germany, ou_persistent22              
4Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634550              
5Center for Cognitive Neuroscience Berlin, Freie Universität Berlin, Berlin, Germany, ou_persistent22              

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Free keywords: Nigrosome; Neuromelanin; Ferritin; Ion beam microscopy
 Abstract: We present a biophysical model that quantitatively describes gradient and spin echo relaxation in substantia nigra induced by iron accumulated the neuromelanin of dopaminergic neurons. This model was informed by 3D quantitative microscopic iron distributions obtained from classical histology and Proton-Induced X-ray Emission. It was validated by comparison to quantitative MRI on post mortem human brain tissue. We demonstrate that the total iron content of DN can be extracted analytically from relaxometry in nigrosomes. This results provides an important step toward a highly desired early stage biomarker for detecting dopaminergic neurons depletion in Parkinson's disease.

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Language(s): eng - English
 Dates: 2018-11-072019-02-072019-04-01
 Publication Status: Published online
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Title: ISMRM 27th Annual Meeting & Exhibition
Place of Event: Palais des congrès de Montréal, 1001 Place Jean-Paul-Riopelle, Montréal, QC, Canada
Start-/End Date: 2019-05-11 - 2019-05-16

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Title: Proceedings of the ISMRM 27th Annual Meeting & Exhibition
Source Genre: Proceedings
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