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  A generic deviance detection principle for cortical on/off responses, omission response, and mismatch negativity

Chien, V., Maess, B., & Knösche, T. R. (2019). A generic deviance detection principle for cortical on/off responses, omission response, and mismatch negativity. Biological Cybernetics. doi:10.1007/s00422-019-00804-x.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-A4E0-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-D837-B
Genre: Journal Article

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 Creators:
Chien, Vincent1, Author              
Maess, Burkhard1, Author              
Knösche, Thomas R.1, Author              
Affiliations:
1Methods and Development Unit - MEG and Cortical Networks, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205650              

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Free keywords: Adaptation; Auditory perception; Deviance detection; NMDA; Neural mass model
 Abstract: Neural responses to sudden changes can be observed in many parts of the sensory pathways at different organizational levels. For example, deviants that violate regularity at various levels of abstraction can be observed as simple On/Off responses of individual neurons or as cumulative responses of neural populations. The cortical deviance-related responses supporting different functionalities (e.g., gap detection, chunking, etc.) seem unlikely to arise from different function-specific neural circuits, given the relatively uniform and self-similar wiring patterns across cortical areas and spatial scales. Additionally, reciprocal wiring patterns (with heterogeneous combinations of excitatory and inhibitory connections) in the cortex naturally speak in favor of a generic deviance detection principle. Based on this concept, we propose a network model consisting of reciprocally coupled neural masses as a blueprint of a universal change detector. Simulation examples reproduce properties of cortical deviance-related responses including the On/Off responses, the omitted-stimulus response (OSR), and the mismatch negativity (MMN). We propose that the emergence of change detectors relies on the involvement of disinhibition. An analysis of network connection settings further suggests a supportive effect of synaptic adaptation and a destructive effect of N-methyl-D-aspartate receptor (NMDA-r) antagonists on change detection. We conclude that the nature of cortical reciprocal wiring gives rise to a whole range of local change detectors supporting the notion of a generic deviance detection principle. Several testable predictions are provided based on the network model. Notably, we predict that the NMDA-r antagonists would generally dampen the cortical Off response, the cortical OSR, and the MMN.

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Language(s): eng - English
 Dates: 2019-03-182019-08-072019-08-19
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1007/s00422-019-00804-x
PMID: 31428855
Other: Epub ahead of print
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Funding organization : Max Planck Society

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Title: Biological Cybernetics
  Other : Biol. Cybern.
Source Genre: Journal
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Publ. Info: Berlin : Springer
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 0340-1200
CoNE: https://pure.mpg.de/cone/journals/resource/954927549307