User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse


  Spectral signatures of serotonergic psychedelics and glutamatergic dissociatives

Pallavicini, C., Vilas, M. G., Villarreal, M., Zamberlan, F., Muthukumaraswamy, S., Nutt, D., et al. (2019). Spectral signatures of serotonergic psychedelics and glutamatergic dissociatives. NeuroImage, 200, 281-291. doi:10.1016/j.neuroimage.2019.06.053.

Item is


show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0004-A0B4-B Version Permalink: http://hdl.handle.net/21.11116/0000-0004-A0B5-A
Genre: Journal Article


show Files




Pallavicini, Carla1, 2, Author
Vilas, Martina G.3, Author              
Villarreal, Mirta1, Author
Zamberlan, Federico2, Author
Muthukumaraswamy, Suresh4, Author
Nutt, David5, Author
Carhart-Harris, Robin5, Author
Tagliazucchi, Enzo2, Author
1Fundación para la lucha contra las enfermedades neurológicas de la infancia (FLENI) , Montañeses 2325, C1428, AQK, Buenos Aires, Argentina, ou_persistent22              
2Departamento de Física, Universidad de Buenos Aires and Instituto de Física de Buenos Aires (IFIBA – CONICET), Pabellón I, Ciudad Universitaria (1428), Buenos Aires, Argentina, ou_persistent22              
3Department of Neuroscience, Max Planck Institute for Empirical Aesthetics, Max Planck Society, ou_2421697              
4University of Auckland Faculty of Medical and Health Sciences, 85 Park Rd, Grafton, Auckland, 1023, New Zealand, ou_persistent22              
5Centre for Neuropsychopharmacology, South Kensington Campus London , SW7 2AZ, London, United Kingdom, ou_persistent22              


Free keywords: Serotonergic psychedelics Ketamine Dissociatives Consciousness Machine learning Magnetoencepalography
 Abstract: Classic serotonergic psychedelics are remarkable for their capacity to induce reversible alterations in consciousness of the self and the surroundings, mediated by agonism at serotonin 5-HT2A receptors. The subjective effects elicited by dissociative drugs acting as N-methyl-D-aspartate (NMDA) antagonists (e.g. ketamine and phencyclidine) overlap in certain domains with those of serotonergic psychedelics, suggesting some potential similarities in the brain activity patterns induced by both classes of drugs, despite different pharmacological mechanisms of action. We investigated source-localized magnetoencephalography recordings to determine the frequency-specific changes in oscillatory activity and long-range functional coupling that are common to two serotonergic compounds (lysergic acid diethylamide [LSD] and psilocybin) and the NMDA-antagonist ketamine. Administration of the three drugs resulted in widespread and broadband spectral power reductions. We established their similarity by using different pairs of compounds to train and subsequently evaluate multivariate machine learning classifiers. After applying the same methodology to functional connectivity values, we observed a pattern of occipital, parietal and frontal decreases in the low alpha and theta bands that were specific to LSD and psilocybin, as well as decreases in the low beta band common to the three drugs. Our results represent a first effort in the direction of quantifying the similarity of large-scale brain activity patterns induced by drugs of different mechanism of action, confirming the link between changes in theta and alpha oscillations and 5-HT2A agonism, while also revealing the decoupling of activity in the beta band as an effect shared between NMDA antagonists and 5-HT2A agonists. We discuss how these frequency-specific convergences and divergences in the power and functional connectivity of brain oscillations might relate to the overlapping subjective effects of serotonergic psychedelics and glutamatergic dissociative compounds.


Language(s): eng - English
 Dates: 2019-06-192019-05-142019-06-212019-06-242019-10-15
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.neuroimage.2019.06.053
 Degree: -



Legal Case


Project information


Source 1

Title: NeuroImage
Source Genre: Journal
Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 200 Sequence Number: - Start / End Page: 281 - 291 Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166