English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Selective toxicity of L-DOPA to dopamine transporter-expressing neurons and locomotor behavior in zebrafish larvae

Stednitz, S., Freshner, B., Shelton, S., Shen, T., Black, D., & Gahtan, E. (2015). Selective toxicity of L-DOPA to dopamine transporter-expressing neurons and locomotor behavior in zebrafish larvae. Neurotoxicology and Teratology, 52 A, 51-56. doi:10.1016/j.ntt.2015.11.001.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0004-A109-C Version Permalink: http://hdl.handle.net/21.11116/0000-0004-A10A-B
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Stednitz, SJ1, Author              
Freshner, B, Author
Shelton, S, Author
Shen, T, Author
Black, D, Author
Gahtan, E, Author
Affiliations:
1External Organizations, ou_persistent22              

Content

show
hide
Free keywords: -
 Abstract: Dopamine signaling is conserved across all animal species and has been implicated in the disease process of many neurological disorders, including Parkinson's disease (PD). The primary neuropathology in PD involves the death of dopaminergic cells in the substantia nigra (SN), an anatomical region of the brain implicated in dopamine production and voluntary motor control. Increasing evidence suggests that the neurotransmitter dopamine may have a neurotoxic metabolic product (DOPAL) that selectively damages dopaminergic cells. This study was designed to test this theory of oxidative damage in an animal model of Parkinson's disease, using a transgenic strain of zebrafish with fluorescent labeling of cells that express the dopamine transporter. The pretectum and ventral diencephalon exhibited reductions in cell numbers due to L-DOPA treatment while reticulospinal neurons that do not express the DAT were unaffected, and this was partially rescued by monoamine oxidase inhibition. Consistent with the MPTP model of PD in zebrafish larvae, spontaneous locomotor behavior in L-DOPA treated animals was depressed following a 24-h recovery period, while visually-evoked startle response rates and latencies were unaffected.

Details

show
hide
Language(s):
 Dates: 2015-11
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1016/j.ntt.2015.11.001
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Neurotoxicology and Teratology
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 52 A Sequence Number: - Start / End Page: 51 - 56 Identifier: -