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haenelt_ohbm2018.pdf (Publisher version), 3MB
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haenelt_ohbm2018.pdf
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Using ultra-high field fMRI makes in vivo examinations of columnar and laminar structures in the human cerebral cortex feasible. However, it is still under debate which acquisition technique is optimal for high-resolution fMRI. Typical acquisition protocols at lower field strengths use GE-EPI , which possesses high BOLD sensitivity but lacks specificity due to large draining veins. Because of the anisotropic macrovascular distribution in the cortex, the needed specificity towards microvascular contributions does also depend on whether columnar or laminar structures are of interest. Here, we compare single-shot 2D GE-EPI and SE-EPI at 7 T in their ability and specificity to delineate colour-selective stripes in extrastriate cortex V2. Participants performed multiple sessions at different days. In single sessions, stimuli consisted either of chromatic or achromatic sinusoidal moving gratings shown in different blocks. GE-EPI and SE-EPI were acquired on different days. V2 was defined based on retinotopy and layers were estimated according to the equi-volume approach. With both sequences, stripes can be reliably identified. The column width across cortical depth is used as a measure for tangential spread. The analysis shall shed light on the issue if GE-EPI is significantly affected in tangential blurring towards the pial surface by delineating cortical columns.
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