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  Reliable 3D mapping of ocular dominance columns in humans using GE-EPI fMRI at 7 T

Haenelt, D., Weiskopf, N., Mueller, R., Nasr, S., Polimeni, J., Tootell, R., et al. (2019). Reliable 3D mapping of ocular dominance columns in humans using GE-EPI fMRI at 7 T. Poster presented at 25th Annual Meeting of the Organization for Human Brain Mapping (OHBM), Rome, Italy.

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 Creators:
Haenelt, Daniel1, 2, Author           
Weiskopf, Nikolaus2, Author           
Mueller, Roland, Author
Nasr, Shahin3, 4, Author
Polimeni, Jonathan3, 4, Author
Tootell, Roger3, 4, Author
Sereno, Martin5, Author
Trampel, Robert2, Author           
Affiliations:
1International Max Planck Research School on Neuroscience of Communication: Function, Structure, and Plasticity, Leipzig, Germany, ou_persistent22              
2Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
3Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, USA, ou_persistent22              
4Department of Radiology, Harvard Medical School, Boston, USA, ou_persistent22              
5Department of Psychology and Neuroimaging Center, San Diego State University, San Diego, USA, ou_persistent22              

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 Abstract: Since the discovery of the BOLD effect, detection of ocular dominance columns (ODCs) in primary visual cortex (V1) served as a benchmark for high-precision functional magnetic resonance imaging (fMRI) (Menon et al., 1997; Dechent and Frahm 2000; Cheng et al., 2001; Yacoub et al., 2007). Although gradient-echo (GE) echo-planar imaging (EPI) is often used at lower field strengths, the applicability for high-resolution fMRI at higher field strengths is still under debate because of its inherent sensitivity to large draining veins (Polimeni et al., 2010). To counteract the loss of specificity, it was recently suggested to only sample far away from the pial surface when using GE-EPI (Nasr et al., 2016; Polimeni et al., 2017). Here, we assessed whether differential ocular dominance responses can be resolved using GE-EPI with different isotropic resolutions (0.8 mm and 1.0 mm) and how the corresponding BOLD signal is distributed across the cortex.

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 Dates: 2019-06
 Publication Status: Not specified
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Title: 25th Annual Meeting of the Organization for Human Brain Mapping (OHBM)
Place of Event: Rome, Italy
Start-/End Date: 2019-06-09 - 2019-06-13

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