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  Comparing functional MRI protocols for small, iron-rich basal ganglia nuclei such as the subthalamic nucleus at 7 T and 3 T

de Hollander, G., Keuken, M. C., van der Zwaag, W., Forstmann, B. U., & Trampel, R. (2017). Comparing functional MRI protocols for small, iron-rich basal ganglia nuclei such as the subthalamic nucleus at 7 T and 3 T. Human Brain Mapping, 38(6), 3226-3248. doi:10.1002/hbm.23586.

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de Hollander, Gilles1, 2, Author
Keuken, Max C.1, 2, Author
van der Zwaag, Wietske3, Author
Forstmann, Birte U.1, 2, 4, Author
Trampel, Robert5, Author              
1Amsterdam Brain and Cognition (ABC), University of Amsterdam, the Netherlands, ou_persistent22              
2The Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands, ou_persistent22              
3Spinoza Centre for Neuroimaging, University of Amsterdam, the Netherlands, ou_persistent22              
4Institute of Psychology, Leiden University, the Netherlands, ou_persistent22              
5Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              


Free keywords: Basal ganglia; Functional neuroimaging; Stop-signal reaction task; Subthalamic nucleus; Ultra-high field MRI
 Abstract: The basal ganglia (BG) form a network of subcortical nuclei. Functional magnetic resonance imaging (fMRI) in the BG could provide insight in its functioning and the underlying mechanisms of Deep Brain Stimulation (DBS). However, fMRI of the BG with high specificity is challenging, because the nuclei are small and variable in their anatomical location. High resolution fMRI at field strengths of 7 Tesla (T) could help resolve these challenges to some extent. A set of MR protocols was developed for functional imaging of the BG nuclei at 3 T and 7 T. The protocols were validated using a stop-signal reaction task (Logan et al. []: J Exp Psychol: Human Percept Perform 10:276-291). Compared with sub-millimeter 7 T fMRI protocols aimed at cortex, a reduction of echo time and spatial resolution was strictly necessary to obtain robust Blood Oxygen Level Dependent (BOLD) sensitivity in the BG. An fMRI protocol at 3 T with identical resolution to the 7 T showed no robust BOLD sensitivity in any of the BG nuclei. The results suggest that the subthalamic nucleus, as well as the substantia nigra, red nucleus, and the internal and external parts of the globus pallidus show increased activation in failed stop trials compared with successful stop and go trials.


Language(s): eng - English
 Dates: 2017-03-092016-11-232017-03-152017-03-272017-06
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/hbm.23586
PMID: 28345164
Other: Epub 2017
 Degree: -



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Project name : -
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Funding program : Starter Grant
Funding organization : European Commission (EC)
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Grant ID : -
Funding program : Vidi Grant
Funding organization : Netherlands Organization for Scientific Research (NWO)

Source 1

Title: Human Brain Mapping
Source Genre: Journal
Publ. Info: New York : Wiley-Liss
Pages: - Volume / Issue: 38 (6) Sequence Number: - Start / End Page: 3226 - 3248 Identifier: ISSN: 1065-9471
CoNE: https://pure.mpg.de/cone/journals/resource/954925601686