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  Content tuning in the medial temporal lobe cortex: Voxels that perceive, retrieve

Schultz, H., Tibon, R., LaRocque, K. F., Gagnon, S. A., Wagner, A. D., & Staresina, B. P. (2019). Content tuning in the medial temporal lobe cortex: Voxels that perceive, retrieve. eNeuro. doi:10.1523/ENEURO.0291-19.2019.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-A91C-F Version Permalink: http://hdl.handle.net/21.11116/0000-0004-A91D-E
Genre: Journal Article

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ENEURO.0291-19.2019.full.pdf (Any fulltext), 2MB
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Copyright © 2019 Schultz et al.
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 Creators:
Schultz, Heidrun1, Author              
Tibon, Roni2, Author
LaRocque, Karen F.3, Author
Gagnon, Stephanie A.3, Author
Wagner, Anthony D.3, Author
Staresina, Bernhard P.1, Author
Affiliations:
1School of Psychology, University of Birmingham, United Kingdom, ou_persistent22              
2MRC Cognition and Brain Sciences Unit, Cambridge, United Kingdom, ou_persistent22              
3Department of Psychology, Stanford University, CA, USA, ou_persistent22              

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Free keywords: Episodic memory; fmri; Hippocampus; Medial temporal lobe; Parahippocampal cortex; Perirhinal cortex
 Abstract: How do we recall vivid details from our past based only on sparse cues? Research suggests that the phenomenological reinstatement of past experiences is accompanied by neural reinstatement of the original percept. This process critically depends on the medial temporal lobe (MTL). Within the MTL, perirhinal cortex (PRC) and parahippocampal cortex (PHC) are thought to support encoding and recall of objects and scenes, respectively, with the hippocampus (HC) serving as a content-independent hub. If the fidelity of recall indeed arises from neural reinstatement of perceptual activity, then successful recall should preferentially draw upon those neural populations within content-sensitive MTL cortex that are tuned to the same content during perception. We tested this hypothesis by having eighteen human participants undergo functional magnetic resonance imaging (fMRI) while they encoded and recalled objects and scenes paired with words. Critically, recall was cued with the words only. While HC distinguished successful from unsuccessful recall of both objects and scenes, PRC and PHC were preferentially engaged during successful vs. unsuccessful object and scene recall, respectively. Importantly, within PRC and PHC, this content-sensitive recall was predicted by content tuning during perception: Across PRC voxels, we observed a positive relationship between object tuning during perception and successful object recall, while across PHC voxels, we observed a positive relationship between scene tuning during perception and successful scene recall. Our results thus highlight content-based roles of MTL cortical regions for episodic memory and reveal a direct mapping between content-specific tuning during perception and successful recall.

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Language(s): eng - English
 Dates: 2019-07-252019-07-272019-08-26
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1523/ENEURO.0291-19.2019
Other: Epub ahead of print
PMID: 31451605
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Title: eNeuro
Source Genre: Journal
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Publ. Info: Washington, DC : Society for Neuroscience
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: CoNE: https://pure.mpg.de/cone/journals/resource/106249492X