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  Principles of ipsilateral and contralateral cortico-cortical connectivity in the mouse

Goulas, A., Uylings, H. B. M., & Hilgetag, C. C. (2017). Principles of ipsilateral and contralateral cortico-cortical connectivity in the mouse. Brain Structure & Function, 222(3), 1281-1295. doi:10.1007/s00429-016-1277-y.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-A930-7 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-DC0C-8
Genre: Journal Article

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 Creators:
Goulas, Alexandros1, 2, Author              
Uylings, Harry B. M.3, Author
Hilgetag, Claus C.1, 4, Author
Affiliations:
1Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Germany, ou_persistent22              
2Max Planck Research Group Neuroanatomy and Connectivity, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_1356546              
3Department of Anatomy and Neuroscience, VU University Medical Center, Amsterdam, the Netherlands, ou_persistent22              
4Department of Health Sciences, Boston University, MA, USA, ou_persistent22              

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Free keywords: Cytoarchitecture; Mouse connectome; Wiring cost
 Abstract: Structural connectivity among cortical areas provides the substrate for information exchange in the cerebral cortex and is characterized by systematic patterns of presence or absence of connections. What principles govern this cortical wiring diagram? Here, we investigate the relation of physical distance and cytoarchitecture with the connectional architecture of the mouse cortex. Moreover, we examine the relation between patterns of ipsilateral and contralateral connections. Our analysis reveals a mirrored and attenuated organization of contralateral connections when compared with ipsilateral connections. Both physical distance and cytoarchitectonic similarity of cortical areas are related to the presence or absence of connections. Notably, our analysis demonstrates that the combination of these factors relates better to cortico-cortical connectivity than each factor in isolation and that the two factors relate differently to ipsilateral and contralateral connectivity. Physical distance is more tightly related to the presence or absence of ipsilateral connections, but its relevance greatly diminishes for contralateral connections, while the contribution of cytoarchitectonic similarity remains relatively stable. Our results, together with similar findings in the cat and macaque cortex, suggest that a common set of principles underlies the macroscale wiring of the mammalian cerebral cortex.

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Language(s): eng - English
 Dates: 2016-03-112016-07-152016-08-062017-04
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1007/s00429-016-1277-y
PMID: 27497948
Other: Epub 2016
 Degree: -

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Project name : -
Grant ID : -
Funding program : Humboldt Research Fellowship
Funding organization : Alexander von Humboldt Foundation
Project name : Funktionelle Kopplung neuronaler Aktivität im ZNS / SFB 936
Grant ID : -
Funding program : -
Funding organization : German Research Foundation (DFG)
Project name : Crossmodales Lernen: Adaptivität, Prädiktion und Interaktion / SFB/TRR 169
Grant ID : -
Funding program : -
Funding organization : German Research Foundation (DFG)

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Title: Brain Structure & Function
  Abbreviation : Brain Struct Funct
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Berlin : Springer
Pages: - Volume / Issue: 222 (3) Sequence Number: - Start / End Page: 1281 - 1295 Identifier: ISSN: 1863-2653
CoNE: https://pure.mpg.de/cone/journals/resource/1863-2653