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  Motor endplate-anatomical, functional, and molecular concepts in the historical perspective

Rudolf, R., Khan, M. M., & Witzemann, V. (2019). Motor endplate-anatomical, functional, and molecular concepts in the historical perspective. Cells, 8(5): 387, pp. 1-20. doi:10.3390/cells8050387.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-A957-C Version Permalink: http://hdl.handle.net/21.11116/0000-0005-5FF1-1
Genre: Journal Article
Alternative Title : Motor Endplate—Anatomical, Functional, and Molecular Concepts in the Historical Perspective

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 Creators:
Rudolf, Rüdiger, Author
Khan, Muzamil Majid, Author
Witzemann, Veit1, 2, 3, 4, Author              
Affiliations:
1Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              
2Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              
3Molecular anatomy of the neuromuscular junction, Max Planck Institute for Medical Research, Max Planck Society, ou_1497727              
4Working Group Witzemann / Koenen, Max Planck Institute for Medical Research, Max Planck Society, ou_1497748              

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Free keywords: history; motor endplate; neuromuscular junction; skeletal muscle; sympathetic innervation; synapse
 Abstract: By mediating voluntary muscle movement, vertebrate neuromuscular junctions (NMJ) play an extraordinarily important role in physiology. While the significance of the nerve-muscle connectivity was already conceived almost 2000 years back, the precise cell and molecular biology of the NMJ have been revealed in a series of fascinating research activities that started around 180 years ago and that continues. In all this time, NMJ research has led to fundamentally new concepts of cell biology, and has triggered groundbreaking advancements in technologies. This review tries to sketch major lines of thought and concepts on NMJ in their historical perspective, in particular with respect to anatomy, function, and molecular components. Furthermore, along these lines, it emphasizes the mutual benefit between science and technology, where one drives the other. Finally, we speculate on potential major future directions for studies on NMJ in these fields.

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Language(s): eng - English
 Dates: 2019-04-202019-04-102019-04-252019-04-27
 Publication Status: Published in print
 Pages: 20
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

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Title: Cells
Source Genre: Journal
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Publ. Info: Basel, Switzerland : MDPI
Pages: - Volume / Issue: 8 (5) Sequence Number: 387 Start / End Page: 1 - 20 Identifier: ISSN: 2073-4409