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  Age-related mapping of intracortical myelin from late adolescence to middle adulthood using T 1 -weighted MRI

Rowley, C. D., Sehmbi, M., Bazin, P.-L., Tardif, C. L., Minuzzi, L., Frey, B. N., et al. (2017). Age-related mapping of intracortical myelin from late adolescence to middle adulthood using T 1 -weighted MRI. Human Brain Mapping, 38(7), 3691-3703. doi:10.1002/hbm.23624.

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Genre: Journal Article

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 Creators:
Rowley, Christopher D.1, Author
Sehmbi, Manpreet1, Author
Bazin, Pierre-Louis2, Author           
Tardif, Christine L.3, Author
Minuzzi, Luciano1, 4, 5, Author
Frey, Benicio N.1, 4, 5, Author
Bock, Nicholas A.1, 6, Author
Affiliations:
1McMaster Integrative Neuroscience Discovery and Study Program, McMaster University, Hamilton, ON, Canada, ou_persistent22              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
3Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montréal, QC, Canada, ou_persistent22              
4Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada, ou_persistent22              
5Women’s Health Concerns Clinic, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada, ou_persistent22              
6Department of Psychology, Neuroscience, and Behaviour, McMaster University, Hamilton, ON, Canada, ou_persistent22              

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Free keywords: Aging; Cerebral cortex; Intracortical myelin; Magnetic resonance imaging
 Abstract: Magnetic resonance imaging (MRI) studies in humans have reported that the T1 -weighted signal in the cerebral cortex follows an inverted "U" trajectory over the lifespan. Here, we investigated the T1 -weighted signal trajectory from late adolescence to middle adulthood in humans to characterize the age range when mental illnesses tend to present, and efficacy of treatments are evaluated. We compared linear to quadratic predictors of age on signal in 67 healthy individuals, 17-45 years old. We investigated ¼, ½, and ¾ depths in the cortex representing intracortical myelin (ICM), in the superficial white matter (SWM), and in a reference deep white matter tract. We found that the quadratic fit was superior in all regions of the cortex, while signal in the SWM and deep white matter showed no global dependence on age over this range. The signal trajectory in any region followed a similar shape regardless of cortical depth. The quadratic fit was analyzed in 70 cortical regions to obtain the age of maximum signal intensity. We found that visual, cingulate, and left ventromedial prefrontal cortices peak first around 34 years old, whereas motor and premotor areas peak latest at ∼38 years. Our analysis suggests that ICM trajectories over this range can be modeled well in small cohorts of subjects using quadratic functions, which are amenable to statistical analysis, thus suitable for investigating regional changes in ICM with disease. This study highlights a novel approach to map ICM trajectories using an age range that coincides with the onset of many mental illnesses.

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Language(s): eng - English
 Dates: 2017-04-102016-12-202017-04-122017-04-302017-07
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1002/hbm.23624
PMID: 28462512
Other: Epub 2017
 Degree: -

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Project name : -
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Funding program : Independent Investigator Award
Funding organization : Brain & Behaviour Research Foundation
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Grant ID : -
Funding program : AFP Innovations Award
Funding organization : Department of Psychiatry and Behavioural Neurosciences, McMaster University

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Title: Human Brain Mapping
Source Genre: Journal
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Publ. Info: New York : Wiley-Liss
Pages: - Volume / Issue: 38 (7) Sequence Number: - Start / End Page: 3691 - 3703 Identifier: ISSN: 1065-9471
CoNE: https://pure.mpg.de/cone/journals/resource/954925601686