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  Similarity and Strength of Glomerular Odor Representations Define a Neural Metric of Sniff-Invariant Discrimination Time

Bhattacharjee, A. S., Konakamchi, S., Turaev, D., Vincis, R., Nunes, D., Dingankar, A. A., et al. (2019). Similarity and Strength of Glomerular Odor Representations Define a Neural Metric of Sniff-Invariant Discrimination Time. Cell Reports, 28(11), 2966-2978. doi:10.1016/j.celrep.2019.08.015.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-ABD4-C Version Permalink: http://hdl.handle.net/21.11116/0000-0004-ABD5-B
Genre: Journal Article

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 Creators:
Bhattacharjee, Anindya S.1, Author
Konakamchi, Sasank1, Author
Turaev, Dmitrij2, 3, Author              
Vincis, Roberto4, Author
Nunes, Daniel5, Author
Dingankar, Atharva A.1, Author
Spors, Hartwig2, 3, Author              
Carleton, Alan4, Author
Kuner, Thomas3, 5, Author
Abraham, Nixon M.1, 3, 4, 5, Author
Affiliations:
1Indian Institute of Science Education and Research (IISER), Pune, Maharashtra, India, ou_persistent22              
2Department of Molecular Neurogenetics, Max Planck Institute of Biophysics, Max Planck Society, ou_2068296              
3WIN Olfactory Dynamics Group, Max Planck Institute for Medical Research, Heidelberg, Germany, ou_persistent22              
4Department of Basic Neurosciences, School of Medicine, University of Geneva, Genève, Switzerland, ou_persistent22              
5Institute of Anatomy and Cell Biology, Heidelberg University, Heidelberg, Germany, ou_persistent22              

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Free keywords: Euclidean distance, intrinsic optical signal imaging, odor discrimination time, olfactory bulb, sniffing
 Abstract: The olfactory environment is first represented by glomerular activity patterns in the olfactory bulb. It remains unclear how these representations intersect with sampling behavior to account for the time required to discriminate odors. Using different chemical classes, we investigate glomerular representations and sniffing behavior during olfactory decision-making. Mice rapidly discriminate odorants and learn to increase sniffing frequency at a fixed latency after trial initiation, independent of odor identity. Relative to the increase in sniffing frequency, monomolecular odorants are discriminated within 10-40 ms, while binary mixtures require an additional 60-70 ms. Intrinsic imaging of glomerular activity in anesthetized and awake mice reveals that Euclidean distance between activity patterns and the time needed for discriminations are anti-correlated. Therefore, the similarity of glomerular patterns and their activation strengths, rather than sampling behavior, define the extent of neuronal processing required for odor discrimination, establishing a neural metric to predict olfactory discrimination time.

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Language(s): eng - English
 Dates: 2019-05-142019-01-142019-07-312019-09-10
 Publication Status: Published online
 Pages: 13
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.celrep.2019.08.015
BibTex Citekey: bhattacharjee_similarity_2019
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Title: Cell Reports
Source Genre: Journal
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Publ. Info: Maryland Heights, MO : Cell Press
Pages: - Volume / Issue: 28 (11) Sequence Number: - Start / End Page: 2966 - 2978 Identifier: ISSN: 2211-1247
CoNE: https://pure.mpg.de/cone/journals/resource/2211-1247