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  The Global ECT-MRI Research Collaboration (GEMRIC): Establishing a multi-site investigation of the neural mechanisms underlying response to electroconvulsive therapy

Oltedal, L., Bartsch, H., Sørhaug, O. J. E., Kessler, U., Abbott, C., Dols, A., et al. (2017). The Global ECT-MRI Research Collaboration (GEMRIC): Establishing a multi-site investigation of the neural mechanisms underlying response to electroconvulsive therapy. NeuroImage: Clinical, 14, 422-432. doi:10.1016/j.nicl.2017.02.009.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-AB9B-D Version Permalink: http://hdl.handle.net/21.11116/0000-0004-DD1E-3
Genre: Journal Article

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 Creators:
Oltedal, Leif1, Author
Bartsch, Hauke1, Author
Sørhaug, Ole Johan Evjenth1, Author
Kessler, Ute1, Author
Abbott, Christopher1, Author
Dols, Annemieke1, Author
Stek, Max L.1, Author
Ersland, Lars1, Author
Emsell, Louise1, Author
van Eijndhoven, Philip1, Author
Argyelan, Miklos1, Author
Tendolkar, Indira1, Author
Nordanskog, Pia1, Author
Hamilton, Paul1, Author
Jorgensen, Martin Balslev1, Author
Sommer, Iris E.1, Author
Heringa, Sophie M.1, Author
Draganski, Bogdan1, 2, Author              
Redlich, Ronny1, Author
Dannlowski, Udo1, Author
Kugel, Harald1, AuthorBouckaert, Filip1, AuthorSienaert, Pascal1, AuthorAnand, Amit1, AuthorEspinoza, Randall1, AuthorNarr, Katherine L.1, AuthorHolland, Dominic1, AuthorDale, Anders M.1, AuthorOedegaard, Ketil J.1, Author more..
Affiliations:
1External Organizations, ou_persistent22              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              

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Free keywords: Electroconvulsive therapy; MRI; Longitudinal; Mega analysis; Multi-site
 Abstract: Major depression, currently the world's primary cause of disability, leads to profound personal suffering and increased risk of suicide. Unfortunately, the success of antidepressant treatment varies amongst individuals and can take weeks to months in those who respond. Electroconvulsive therapy (ECT), generally prescribed for the most severely depressed and when standard treatments fail, produces a more rapid response and remains the most effective intervention for severe depression. Exploring the neurobiological effects of ECT is thus an ideal approach to better understand the mechanisms of successful therapeutic response. Though several recent neuroimaging studies show structural and functional changes associated with ECT, not all brain changes associate with clinical outcome. Larger studies that can address individual differences in clinical and treatment parameters may better target biological factors relating to or predictive of ECT-related therapeutic response. We have thus formed the Global ECT-MRI Research Collaboration (GEMRIC) that aims to combine longitudinal neuroimaging as well as clinical, behavioral and other physiological data across multiple independent sites. Here, we summarize the ECT sample characteristics from currently participating sites, and the common data-repository and standardized image analysis pipeline developed for this initiative. This includes data harmonization across sites and MRI platforms, and a method for obtaining unbiased estimates of structural change based on longitudinal measurements with serial MRI scans. The optimized analysis pipeline, together with the large and heterogeneous combined GEMRIC dataset, will provide new opportunities to elucidate the mechanisms of ECT response and the factors mediating and predictive of clinical outcomes, which may ultimately lead to more effective personalized treatment approaches.

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Language(s): eng - English
 Dates: 2017-02-092016-12-152017-02-102017-02-14
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.nicl.2017.02.009
PMC: PMC5328749
PMID: 28275543
Other: eCollection 2017
 Degree: -

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Funding organization : Western Norway Regional Health Authority
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Funding organization : Haukeland University Hospital
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Funding organization : University of Bergen, Norway
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Funding organization : Lundbeck Foundation
Project name : Neurobiologie affektiver Störungen: Eine translationale Perspektive auf Hirnstruktur und -funktion / FOR 2107
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Funding organization : German Research Foundation (DFG)
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Grant ID : RE111604
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Funding organization : Innovative Medizinische Forschung
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Grant ID : 2P20GM103472-01
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Funding organization : Centers of Biomedical Research Excellence
Project name : NCCR Synapsy
Grant ID : 32003B_159780
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Funding organization : Swiss National Science Foundation
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Funding organization : Foundation Parkinson Switzerland
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Funding organization : Foundation Synapsis
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Funding organization : Roger de Spoelberch and Partridge Foundations
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Grant ID : R01MH092301; K24MH102743
Funding program : -
Funding organization : National Institute of Mental Health (NIMH)

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Title: NeuroImage: Clinical
Source Genre: Journal
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Publ. Info: Elsevier
Pages: - Volume / Issue: 14 Sequence Number: - Start / End Page: 422 - 432 Identifier: ISSN: 2213-1582
CoNE: https://pure.mpg.de/cone/journals/resource/2213-1582