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  The relationship between glial cell mechanosensitivity and foreign body reactions in the central nervous system

Moshayedi, P., Ng, G., Kwok, J. C. F., Yeo, G. S. H., Bryant, C. E., Fawcett, J. W., et al. (2014). The relationship between glial cell mechanosensitivity and foreign body reactions in the central nervous system. BIOMATERIALS, 35(13), 3919-3925. doi:10.1016/j.biomaterials.2014.01.038.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-B10A-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-B10B-8
Genre: Journal Article

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 Creators:
Moshayedi, Pouria1, Author
Ng, Gilbert1, Author
Kwok, Jessica C. F.1, Author
Yeo, Giles S. H.1, Author
Bryant, Clare E.1, Author
Fawcett, James W.1, Author
Franze, Kristian1, Author
Guck, Jochen2, Author              
Affiliations:
1external, ou_persistent22              
2External Organizations, ou_persistent22              

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Free keywords: Gliosis; Implant; FBR; Astrocyte; Microglia; Stiffness;
 Abstract: Devices implanted into the body become encapsulated due to a foreign body reaction. In the central nervous system (CNS), this can lead to loss of functionality in electrodes used to treat disorders. Around CNS implants, glial cells are activated, undergo gliosis and ultimately encapsulate the electrodes. The primary cause of this reaction is unknown. Here we show that the mechanical mismatch between nervous tissue and electrodes activates glial cells. Both primary rat microglial cells and astrocytes responded to increasing the contact stiffness from physiological values (G' similar to 100 Pa) to shear moduli G' >= 10 kPa by changes in morphology and upregulation of inflammatory genes and proteins. Upon implantation of composite foreign bodies into rat brains, foreign body reactions were significantly enhanced around their stiff portions in vivo. Our results indicate that CNS glial cells respond to mechanical cues, and suggest that adapting the surface stiffness of neural implants to that of nervous tissue could minimize adverse reactions and improve biocompatibility. (C) 2014 The Authors. Published by Elsevier Ltd. All rights reserved.

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Language(s): eng - English
 Dates: 2014
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Degree: -

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Title: BIOMATERIALS
Source Genre: Journal
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Publ. Info: THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND : ELSEVIER SCI LTD
Pages: - Volume / Issue: 35 (13) Sequence Number: - Start / End Page: 3919 - 3925 Identifier: ISSN: 0142-9612